(Q34703558)

4 August 2017

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title

Potential novel targets for Alzheimer pharmacotherapy: I. Secretases (English)

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4 August 2017

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Maiorini AF

1

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4 August 2017

Gaunt MJ

2

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4 August 2017

Jacobsen TM

3

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4 August 2017

McKay AE

4

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4 August 2017

Waldman LD

5

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4 August 2017

Raffa RB

6

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4 August 2017

publication date

1 June 2002

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Journal of Clinical Pharmacy and Therapeutics

4 August 2017

published in

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4 August 2017

volume

27

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4 August 2017

issue

3

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4 August 2017

page(s)

169-183

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Conditions associated with Alzheimer's disease at death: case-control study.

4 August 2017

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One of the antigenic determinants of paired helical filaments is related to tau protein.

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

21 January 2018

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis.

21 January 2018

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

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Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

21 January 2018

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

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Association of microglia with amyloid plaques in brains of APP23 transgenic mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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beta-peptide immunization: a possible new treatment for Alzheimer disease

21 January 2018

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Regulation of APP cleavage by alpha-, beta- and gamma-secretases

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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The role of A beta 42 in Alzheimer's disease

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

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Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

21 January 2018

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Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein

21 January 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

21 January 2018

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The role of the amyloid protein precursor (APP) in Alzheimer's disease: does the normal function of APP explain the topography of neurodegeneration?

21 January 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

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21 January 2018

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Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Evidence for a physical interaction between presenilin and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Neuroscience. An accomplice for gamma-secretase brought into focus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Estrogen and the treatment of Alzheimer's disease

21 January 2018

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Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia

21 January 2018

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Potential role of muscarinic agonists in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

A 5-month, randomized, placebo-controlled trial of galantamine in AD. The Galantamine USA-10 Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2710.2002.00415.X

10.1046/J.1365-2710.2002.00415.X

21 January 2018

Identifiers

DOI

1 reference

4 August 2017

1 reference