(Q34755080)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2 (English)

1 reference

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24 January 2020

6

1 reference

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24 January 2020

author name string

Brandon C Sos

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Charles Harris

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Sarah M Nordstrom

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Jennifer L Tran

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Mercedesz Balázs

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Maria Febbraio

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Milana A B Applegate

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Kay-Uwe Wagner

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Ethan J Weiss

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

English

0 references

publication date

1 April 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

number of pages

12

1 reference

Journal of Clinical Investigation

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

1412-1423

1 reference

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describes a project that uses

24 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3069761/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism

7 July 2018

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7 July 2018

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7 July 2018

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Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver

7 July 2018

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Role of growth hormone in regulating lipolysis, proteolysis, and hepatic glucose production during fasting

7 July 2018

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Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

7 July 2018

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Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

7 July 2018

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Is adipose tissue lipolysis always an adaptive response to starvation?: implications for non-alcoholic fatty liver disease.

7 July 2018

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

7 July 2018

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Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver--a role for growth hormone in alternative exon usage

7 July 2018

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Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

7 July 2018

1 reference

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Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus

7 July 2018

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Recent advances in growth hormone signaling

7 July 2018

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Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway

7 July 2018

1 reference

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Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

7 July 2018

1 reference

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SOCS2 negatively regulates growth hormone action in vitro and in vivo

7 July 2018

1 reference

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

7 July 2018

1 reference

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In vivo analysis of growth hormone receptor signaling domains and their associated transcripts

7 July 2018

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7 July 2018

The Janus kinases (Jaks)

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Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

7 July 2018

1 reference

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Regulation of fatty acid transport by fatty acid translocase/CD36

7 July 2018

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Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

7 July 2018

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The JAK/STAT signaling pathway

7 July 2018

1 reference

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Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice

7 July 2018

1 reference

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Effects of growth hormone on lipid metabolism in humans.

7 July 2018

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Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

7 July 2018

1 reference

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Consequences of growth hormone (GH) overexpression and GH resistance

7 July 2018

1 reference

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Stats: transcriptional control and biological impact

7 July 2018

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Nonalcoholic fatty liver disease

7 July 2018

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Fatty acid transport proteins: a current view of a growing family

7 July 2018

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PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

7 July 2018

1 reference

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Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia

7 July 2018

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Cytokines in alcoholic and nonalcoholic steatohepatitis

7 July 2018

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Metformin reverses fatty liver disease in obese, leptin-deficient mice

7 July 2018

1 reference

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Gigantism in mice lacking suppressor of cytokine signalling-2

7 July 2018

1 reference

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Cytokines in alcoholic liver disease

7 July 2018

1 reference

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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

7 July 2018

1 reference

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Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice

7 July 2018

1 reference

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

7 July 2018

1 reference

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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

7 July 2018

1 reference

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

7 July 2018

1 reference

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Jak2 is essential for signaling through a variety of cytokine receptors

7 July 2018

1 reference

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PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

7 July 2018

1 reference

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A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

7 July 2018

1 reference

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Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

7 July 2018

1 reference

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Molecular basis of the little mouse phenotype and implications for cell type-specific growth

7 July 2018

1 reference

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Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis

7 July 2018

1 reference

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A single arginine residue determines species specificity of the human growth hormone receptor

7 July 2018

1 reference

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Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

7 July 2018

1 reference

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Mode of action of pituitary growth hormone on target cells

7 July 2018

1 reference

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Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Sexual dimorphism in the control of growth hormone secretion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Growth hormone and lipids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Liver-derived IGF-I regulates GH secretion at the pituitary level in mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

STAT5b is required for GH-induced liver IGF-I gene expression.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Growth Hormone Reverses Nonalcoholic Steatohepatitis in a Patient With Adult Growth Hormone Deficiency

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069761

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration

9 December 2018

1 reference

12 December 2020

The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity

1 reference

12 December 2020

STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain

1 reference

12 December 2020

Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol

1 reference

12 December 2020

TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)

1 reference

12 December 2020

Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin

1 reference

12 December 2020

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice

1 reference

12 December 2020

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

1 reference

12 December 2020

Influence of previous feeding with a high-fat diet on liver steatosis produced by acute starvation or growth hormone in mice

1 reference

12 December 2020

Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques

1 reference

12 December 2020

The expression of a metallothionein-ovine growth hormone fusion gene in transgenic mice does not impair fertility but results in pathological lesions in the liver

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI42894

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21364286%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

21364286

1 reference