(Q34775438)

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From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

Trypanosoma brucei

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1 reference

based on heuristic

inferred from title

Andrew Woodland

object named as

Andrew Woodland

1

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object named as

Ruth Brenk

7

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object named as

Paul G Wyatt

10

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object named as

Ian H Gilbert

9

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author name string

Raffaella Grimaldi

2

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Europe PubMed Central

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4 August 2017

Torsten Luksch

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

Laura A T Cleghorn

4

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Europe PubMed Central

PubMed publication ID

4 August 2017

Kayode K Ojo

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Wesley C Van Voorhis

6

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Europe PubMed Central

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4 August 2017

Julie A Frearson

8

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Europe PubMed Central

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4 August 2017

publication date

14 June 2013

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Europe PubMed Central

PubMed publication ID

4 August 2017

8

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Europe PubMed Central

PubMed publication ID

4 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1127-1137

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Recent results in protein kinase inhibition for tropical diseases

1 reference

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Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.

1 reference

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7 July 2018

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

1 reference

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7 July 2018

Development of novel drugs for human African trypanosomiasis

1 reference

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7 July 2018

Drug discovery and development for neglected diseases: the DNDi model

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High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

1 reference

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7 July 2018

Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors

1 reference

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7 July 2018

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

1 reference

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7 July 2018

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness

1 reference

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7 July 2018

Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.

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7 July 2018

The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases

1 reference

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7 July 2018

NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

1 reference

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7 July 2018

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei

1 reference

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7 July 2018

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

1 reference

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7 July 2018

QMEAN server for protein model quality estimation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Kinetoplastids: related protozoan pathogens, different diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Doing more than just the structure-structural genomics in kinase drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

QMEAN: A comprehensive scoring function for model quality assessment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

The selectivity of protein kinase inhibitors: a further update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Drug discovery and development for neglected parasitic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

7 July 2018

Protein kinases as drug targets in trypanosomes and Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728731

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Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

1 reference

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Pharmacological inhibitors of glycogen synthase kinase 3.

1 reference

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7 July 2018

GSK3 inhibitors: development and therapeutic potential

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300072

21 January 2018

Identifiers

10.1002/CMDC.201300072

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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