(Q34792888)

4 August 2017

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry (English)

1 reference

4 August 2017

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8

1 reference

4 August 2017

9

Alison E Ashcroft

0 references

Lydia M Young

Lydia M Young

1

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Ling-Hsien Tu

Ling-Hsien Tu

6

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Daniel P Raleigh

Daniel P Raleigh

7

0 references

Richard Foster

Richard J Foster

5

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author name string

Janet C Saunders

2

1 reference

PubMed ID

25515893

4 August 2017

Rachel A Mahood

3

1 reference

PubMed ID

25515893

4 August 2017

Charlotte H Revill

4

1 reference

4 August 2017

8 December 2014

1 reference

4 August 2017

9

1 reference

full work available at URL

inferred from page(s)

http://eprints.whiterose.ac.uk/85627/

content deliverer

White Rose Research Online

0 references

published in

Nature Chemistry

1 reference

4 August 2017

7

1 reference

4 August 2017

1

1 reference

4 August 2017

73-81

1 reference

https://scigraph.springernature.com/pub.10.1038/nchem.2129

4 August 2017

0 references

cites work

Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors

1 reference

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Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation

8 July 2018

1 reference

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Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Amyloid in the islets of Langerhans: thoughts and some historical aspects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Inhibition of glycosaminoglycan-mediated amyloid formation by islet amyloid polypeptide and proIAPP processing intermediates

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Identifying nonspecific ligand binding in electrospray ionization mass spectrometry using the reporter molecule method

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Small-molecule aggregates inhibit amyloid polymerization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Alzhemed: a potential treatment for Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

A deconvolution method for the separation of specific versus nonspecific interactions in noncovalent protein-ligand complexes analyzed by ESI-FT-ICR mass spectrometry.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Applications of a travelling wave-based radio-frequency-only stacked ring ion guide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Influence of solution and gas phase processes on protein-carbohydrate binding affinities determined by nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Aspirin and diabetes: inhibition of amylin aggregation by nonsteroidal anti-inflammatory drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Alzheimer's disease: genes, proteins, and therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Diversity screening versus focussed screening in drug discovery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Rational design of potent human transthyretin amyloid disease inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280571

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Is Congo red an amyloid-specific dye?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

Method for distinguishing specific from nonspecific protein-ligand complexes in nanoelectrospray ionization mass spectrometry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25515893

12 December 2020

inferred from PubMed ID database lookup

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25515893

12 December 2020

inferred from PubMed ID database lookup

Monitoring oligomer formation from self-aggregating amylin peptides using ESI-IMS-MS

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.2129

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEM.2129

1 reference

Dimensions Publication ID

4 August 2017

0 references

0 references

1 reference

4 August 2017

1 reference

PubMed ID

25515893