(Q35076599)

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Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Alison E. Ashcroft

4

object named as

Alison E Ashcroft

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object named as

Lydia M Young

1

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Daniel P Raleigh

object named as

Daniel P Raleigh

3

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author name string

Ping Cao

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

language of work or name

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publication date

30 December 2013

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Europe PubMed Central

PubMed publication ID

6 August 2017

number of pages

11

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full work available at URL

http://eprints.whiterose.ac.uk/80190/

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White Rose Research Online

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published version

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Creative Commons Attribution 4.0 International

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https://doi.org/10.1021/ja406831n

copyright license

Creative Commons Attribution 4.0 International

object has role

published version

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Journal of the American Chemical Society

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Europe PubMed Central

PubMed publication ID

6 August 2017

136

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

660-670

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Twenty years of gas phase structural biology.

1 reference

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Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils

1 reference

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8 July 2018

Amylin uncovered: a review on the polypeptide responsible for type II diabetes.

1 reference

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8 July 2018

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.

1 reference

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8 July 2018

Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity

1 reference

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Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry

1 reference

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8 July 2018

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

1 reference

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8 July 2018

Advances in ion mobility spectrometry-mass spectrometry reveal key insights into amyloid assembly

1 reference

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8 July 2018

Ionic strength effects on amyloid formation by amylin are a complicated interplay among Debye screening, ion selectivity, and Hofmeister effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928500

8 July 2018

Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption

1 reference

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8 July 2018

Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor

1 reference

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8 July 2018

Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols

1 reference

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8 July 2018

Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible link between coffee consumption and diabetes mellitus

1 reference

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8 July 2018

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

1 reference

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8 July 2018

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus

1 reference

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A diversity of assembly mechanisms of a generic amyloid fold

1 reference

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8 July 2018

The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces

1 reference

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8 July 2018

Amyloid in the islets of Langerhans: thoughts and some historical aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928500

8 July 2018

Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928500

8 July 2018

Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids

1 reference

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8 July 2018

Combination of kinetically selected inhibitors in trans leads to highly effective inhibition of amyloid formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928500

8 July 2018

The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928500

8 July 2018

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

1 reference

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Molecular recognition at protein surface in solution and gas phase: Five VEGF peptidic ligands show inverse affinity when studied by NMR and CID-MS.

1 reference

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8 July 2018

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

1 reference

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8 July 2018

Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3928500

8 July 2018

The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors

1 reference

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Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

1 reference

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Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide

1 reference

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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

1 reference

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Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

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Determination of stoichiometry and conformational changes in the first step of the P22 tail assembly

1 reference

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Small-molecule aggregates inhibit amyloid polymerization

1 reference

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8 July 2018

Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers

1 reference

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8 July 2018

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells

1 reference

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8 July 2018

Protein misfolding, functional amyloid, and human disease

1 reference

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Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

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Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

1 reference

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Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.

1 reference

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1 reference

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1 reference

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

1 reference

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1 reference

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12 December 2020

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Identifiers

10.1021/JA406831N

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

10.1021/JA406831N

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

ResearchGate publication ID

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2-s2.0-84892750977

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