(Q34837180)

4 August 2017

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title

Promising therapeutic targets for antileishmanial drugs (English)

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4 August 2017

Karl A Werbovetz

1

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4 August 2017

language of work or name

English

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publication date

1 August 2002

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Expert Opinion on Therapeutic Targets

4 August 2017

published in

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4 August 2017

volume

6

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4 August 2017

issue

4

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4 August 2017

page(s)

407-422

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Parasitology: the dawn of a new millennium

4 August 2017

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Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

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Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

21 January 2018

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The therapeutic potential of inhibitors of the trypanothione cycle

21 January 2018

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Enzymes of parasite thiol metabolism as drug targets

21 January 2018

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Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines

21 January 2018

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Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani

21 January 2018

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Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo[2,1-b]quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST proc

21 January 2018

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In vitro leishmanicidal activity of monomeric and dimeric naphthoquinones.

21 January 2018

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QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives

21 January 2018

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Genetic analysis of spermidine synthase from Leishmania donovani

21 January 2018

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Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes

21 January 2018

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The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages

21 January 2018

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Putrescine and spermidine transport in Leishmania.

21 January 2018

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Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines

21 January 2018

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Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase

21 January 2018

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Novel inhibitors of Leishmanial dihydrofolate reductase.

21 January 2018

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The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

21 January 2018

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Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

21 January 2018

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Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

21 January 2018

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Cysteine proteases of parasitic organisms

21 January 2018

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Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

21 January 2018

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Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors

21 January 2018

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target

21 January 2018

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Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana

21 January 2018

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Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana

21 January 2018

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The promastigote surface protease (gp63) of Leishmania is expressed but differentially processed and localized in the amastigote stage

21 January 2018

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Anti-AIDS drugs available 'at cost'.

21 January 2018

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Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle

21 January 2018

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Mode of action of benzimidazoles

21 January 2018

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Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics

21 January 2018

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Purification, characterization, and drug susceptibility of tubulin from Leishmania

21 January 2018

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The biochemistry of compounds with anti-microtubule activity in plant cells

21 January 2018

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Inhibition of leishmanias but not host macrophages by the antitubulin herbicide trifluralin

21 January 2018

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Herbicides to curb human parasitic infections: in vitro and in vivo effects of trifluralin on the trypanosomatid protozoans

21 January 2018

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Uptake and mode of action of drugs used against sleeping sickness.

21 January 2018

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Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei

21 January 2018

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Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Effects of cationic diamidines on polyamine content and uptake on Leishmania infantum in in vitro cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

In vitro leishmanicidal activity of naturally occurring chalcones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

The role of succinate in the respiratory chain of Trypanosoma brucei procyclic trypomastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

In vitro antimalarial activity of chalcones and their derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Glycolysis as a target for the design of new anti-trypanosome drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Crystal Structure of Glycosomal Glyceraldehyde-3-phosphate Dehydrogenase from Leishmania mexicana: Implications for Structure-Based Drug Design and a New Position for the Inorganic Phosphate Binding Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Characterisation of the gene encoding type II DNA topoisomerase from Leishmania donovani: a key molecular target in antileishmanial therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.4.407

21 January 2018

Identifiers

DOI

10.1517/14728222.6.4.407

1 reference

4 August 2017

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