(Q34935948)

5 August 2017

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title

RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer (English)

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5 August 2017

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Frederic J Kaye

1

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PubMed ID

12362273

5 August 2017

language of work or name

English

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publication date

1 October 2002

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5 August 2017

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5 August 2017

21

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5 August 2017

6908-6914

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5 August 2017

45

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205834

5 August 2017

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cites work

Third (fourth and fifth) nonocular tumors in survivors of retinoblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Pathways governing G1/S transition and their response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Ras oncogene mutations in thyroid tumors: polymerase chain reaction-restriction-fragment-length polymorphism analysis from paraffin-embedded tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

RB and the cell cycle: entrance or exit?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Physical interaction of the retinoblastoma protein with human D cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Mortality from second tumors among long-term survivors of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Epidermal growth factor receptor family in lung cancer and premalignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The Rb/E2F pathway: expanding roles and emerging paradigms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

HER2/neu expression in malignant lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Effects of an Rb mutation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

A cell cycle regulator potentially involved in genesis of many tumor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

CDKN2 in HPV-positive and HPV-negative cervical-carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

How many tumor suppressor genes are involved in human lung carcinogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Expression and amplification of the N-myc gene in primary retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The retinoblastoma gene family in differentiation and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Potential of 5-aza-2'-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Retinoblastoma protein partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Human small-cell lung cancers show amplification and expression of the N-myc gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Non-ocular cancer in relatives of retinoblastoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Signaling networks that link cell proliferation and cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Role of the retinoblastoma protein in the pathogenesis of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Preclinical and clinical development of cyclin-dependent kinase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The INK4a/ARF network in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

A bird's eye view of global methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

P16 gene in uncultured tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Origin of human small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Hereditary retinoblastoma and risk of lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Cyclin D-dependent kinases, INK4 inhibitors and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Identification and characterization of families with aggregation of lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Molecular Pathogenesis of Lung Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205834

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205834

1 reference

PubMed ID

12362273

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

12362273