(Q34970234)

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Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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7

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Harma Ellens

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

9

object named as

Joe Bentz

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Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Annie Albin Lumen

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Libin Li

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Jiben Li

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Zeba Ahmed

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Zhou Meng

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Albert Owen

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Ismael J Hidalgo

8

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Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

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publication date

16 August 2013

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Europe PubMed Central

PubMed publication ID

5 August 2017

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Europe PubMed Central

PubMed publication ID

5 August 2017

8

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Europe PubMed Central

PubMed publication ID

5 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

e69394

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

copyright license

Creative Commons CC0 License

16 August 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so.

1 reference

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8 July 2018

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

1 reference

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8 July 2018

Colloidal aggregation affects the efficacy of anticancer drugs in cell culture

1 reference

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8 July 2018

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm

1 reference

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8 July 2018

Coexistence of passive and carrier-mediated processes in drug transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

Membrane transporters in drug development

1 reference

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8 July 2018

Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies

1 reference

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8 July 2018

If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

1 reference

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P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib

1 reference

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8 July 2018

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

1 reference

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8 July 2018

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

1 reference

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8 July 2018

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

Screening in a spirit haunted world

1 reference

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8 July 2018

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

1 reference

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8 July 2018

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

1 reference

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8 July 2018

Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

1 reference

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8 July 2018

Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

1 reference

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8 July 2018

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

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8 July 2018

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745465

8 July 2018

P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

1 reference

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The influence of cholesterol on phospholipid membrane curvature and bending elasticity

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A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

1 reference

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Modulation of P-glycoprotein Transport Activity in the Mouse Blood-Brain Barrier by Rifampin

1 reference

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Establishment of in vitro P-glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug-drug interaction at the drug discovery stage.

1 reference

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Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers

1 reference

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Characterization of digoxin uptake in sandwich-cultured human hepatocytes.

1 reference

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Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

1 reference

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1 reference

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12 December 2020

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Identifiers

10.1371/JOURNAL.PONE.0069394

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2013PLoSO...869394L

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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