(Q34977328)

5 August 2017

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title

Tryptophan synthase: a mine for enzymologists (English)

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5 August 2017

2

Stefano Bettati

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5 August 2017

Andrea Mozzarelli

3

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Samanta Raboni

object named as

Samanta Raboni

series ordinal

1

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publication date

22 April 2009

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Cellular and Molecular Life Sciences

5 August 2017

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5 August 2017

66

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5 August 2017

14

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5 August 2017

2391-2403

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0028-0

5 August 2017

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cites work

Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0028-0

Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0028-0

The molecular pathway for the allosteric regulation of tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0028-0

Allosteric communication between alpha and beta subunits of tryptophan synthase: modelling the open-closed transition of the alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0028-0

Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0028-0

Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase

21 January 2018

1 reference

12 December 2020

Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex

1 reference

12 December 2020

On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes

1 reference

12 December 2020

The interconversion of E. coli tryptophan synthase intermediates is modulated by allosteric interactions.

1 reference

12 December 2020

Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit

1 reference

12 December 2020

Mechanism of activation of the tryptophan synthase alpha2beta2 complex. Solvent effects of the co-substrate beta-mercaptoethanol

1 reference

12 December 2020

Stereoelectronic control of bond formation in Escherichia coli tryptophan synthase: substrate specificity and enzymatic synthesis of the novel amino acid dihydroisotryptophan

1 reference

12 December 2020

Rational herbicide design by inhibition of tryptophan biosynthesis.

1 reference

12 December 2020

Microspectrophotometric studies on single crystals of the tryptophan synthase alpha 2 beta 2 complex demonstrate formation of enzyme-substrate intermediates

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12 December 2020

Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase

1 reference

12 December 2020

Mutations in the contact region between the alpha and beta subunits of tryptophan synthase alter subunit interaction and intersubunit communication

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12 December 2020

The molecular basis of substrate channeling

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12 December 2020

Tryptophan synthase alpha subunit glutamic acid 49 is essential for activity. Studies with 19 mutants at position 49.

1 reference

12 December 2020

The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25-30 A long tunnel

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12 December 2020

Stereochemistry and mechanism of reactions catalyzed by tryptophanase and tryptophan synthetase

1 reference

12 December 2020

Monovalent metal ions play an essential role in catalysis and intersubunit communication in the tryptophan synthase bienzyme complex

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12 December 2020

Modeling of the spatial structure of eukaryotic ornithine decarboxylases

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12 December 2020

The mechanism of binding of L-serine to tryptophan synthase from Escherichia coli.

1 reference

12 December 2020

Protein architecture, dynamics and allostery in tryptophan synthase channeling

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12 December 2020

Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium

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12 December 2020

Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding

1 reference

12 December 2020

Crystal structure of the beta Ser178--> Pro mutant of tryptophan synthase. A "knock-out" allosteric enzyme

1 reference

12 December 2020

Pressure and temperature jump relaxation kinetics of the conformational change in Salmonella typhimurium tryptophan synthase L-serine complex: large activation compressibility and heat capacity changes demonstrate the contribution of solvation

1 reference

12 December 2020

Time-resolved fluorescence of tryptophan synthase.

1 reference

12 December 2020

Loop closure and intersubunit communication in tryptophan synthase

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12 December 2020

Investigation of allosteric linkages in the regulation of tryptophan synthase: the roles of salt bridges and monovalent cations probed by site-directed mutation, optical spectroscopy, and kinetics

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12 December 2020

Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate

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12 December 2020

The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole

1 reference

12 December 2020

On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase

1 reference

12 December 2020

Conformational changes and subunit communication in tryptophan synthase: effect of substrates and substrate analogs

1 reference

12 December 2020

Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase

1 reference

12 December 2020

Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

1 reference

12 December 2020

Lysine 87 in the beta subunit of tryptophan synthase that forms an internal aldimine with pyridoxal phosphate serves critical roles in transimination, catalysis, and product release

1 reference

12 December 2020

Serine modulates substrate channeling in tryptophan synthase. A novel intersubunit triggering mechanism

1 reference

12 December 2020

Molecular Models of Tryptophan Synthase From Mycobacterium tuberculosis Complexed With Inhibitors

1 reference

12 December 2020

Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex

1 reference

12 December 2020

The Tryptophan Synthase from Escherichia coli. An Improved Purification Procedure for the alpha-Subunit and Binding Studies with Substrate Analogues

1 reference

12 December 2020

Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase alpha-, beta-, and alpha beta-reactions

1 reference

12 December 2020

BetaQ114N and betaT110V mutations reveal a critically important role of the substrate alpha-carboxylate site in the reaction specificity of tryptophan synthase

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12 December 2020

Kinetic characterization of channel impaired mutants of tryptophan synthase.

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12 December 2020

Tryptophan synthase, an allosteric molecular factory

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12 December 2020

Identification of the geometric requirements for allosteric communication between the alpha- and beta-subunits of tryptophan synthase

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12 December 2020

Confinement and crowding effects on tryptophan synthase α2β2complex

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12 December 2020

Kinetic spectroscopic studies of substrate and subunit interactions of tryptophan synthetase

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12 December 2020

Role of pyridoxal 5'-phosphate in the structural stabilization of O-acetylserine sulfhydrylase.

1 reference

12 December 2020

Tryptophan synthase: the workings of a channeling nanomachine

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12 December 2020

Microcrystals of tryptophan synthase alpha 2 beta 2 complex from Salmonella typhimurium are catalytically active.

1 reference

12 December 2020

The alpha subunit of tryptophan synthase. Evidence that aspartic acid 60 is a catalytic residue and that the double alteration of residues 175 and 211 in a second-site revertant restores the proper geometry of the substrate binding site.

1 reference

12 December 2020

Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase

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12 December 2020

Protozoan genomics for drug discovery.

1 reference

12 December 2020

Elevated amino acid biosynthesis in Phytophthora infestans during appressorium formation and potato infection

1 reference

12 December 2020

Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the beta-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium

1 reference

12 December 2020

The catalytic mechanism of tryptophan synthase from Escherichia coli. Kinetics of the reaction of indole with the enzyme--L-serine complexes

1 reference

12 December 2020

Allosteric interactions coordinate catalytic activity between successive metabolic enzymes in the tryptophan synthase bienzyme complex

1 reference

12 December 2020

Mechanisms of monovalent cation action in enzyme catalysis: the first stage of the tryptophan synthase beta-reaction

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12 December 2020

Tryptophan Synthase: Structure, Function, and Subunit Interaction

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12 December 2020

Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands

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12 December 2020

Stereochemistry of the tryptophan synthetase reaction

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12 December 2020

Effect of pH and Monovalent Cations on the Formation of Quinonoid Intermediates of the Tryptophan Synthase α2β2Complex in Solution and in the Crystal

1 reference

12 December 2020

Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase

1 reference

12 December 2020

Evidence that glutamic acid 49 of tryptophan synthase alpha subunit is a catalytic residue. Inactive mutant proteins substituted at position 49 bind ligands and transmit ligand-dependent to the beta subunit.

1 reference

12 December 2020

Detection of open and closed conformations of tryptophan synthase by 15N-heteronuclear single-quantum coherence nuclear magnetic resonance of bound 1-15N-L-tryptophan

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12 December 2020

Structural basis for catalysis by tryptophan synthase

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12 December 2020

Allosteric communication of tryptophan synthase. Functional and regulatory properties of the beta S178P mutant

1 reference

12 December 2020

Origin of the mutual activation of the alpha and beta 2 subunits in the alpha 2 beta 2 complex of tryptophan synthase. Effect of alanine or glycine substitutions at proline residues in the alpha subunit

1 reference

12 December 2020

Plasticity of the Tryptophan Synthase Active Site Probed by31P NMR Spectroscopy

1 reference

12 December 2020

Tryptophan synthase. Structure, function, and protein engineering

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12 December 2020

Robust Salmonella metabolism limits possibilities for new antimicrobials.

1 reference

12 December 2020

Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex

1 reference

12 December 2020

Regulation of tryptophan synthase by temperature, monovalent cations, and an allosteric ligand. Evidence from Arrhenius plots, absorption spectra, and primary kinetic isotope effects

1 reference

12 December 2020

Characterization of tryptophan and coenzyme luminescence in tryptophan synthase from Salmonella typhimurium

1 reference

12 December 2020

Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha 2 beta 2 complex.

1 reference

12 December 2020

Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis

1 reference

12 December 2020

Detection and identification of intermediates in the reaction of L-serine with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

1 reference

12 December 2020

Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

1 reference

12 December 2020

Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase

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12 December 2020

Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity

1 reference

12 December 2020

Allosteric linkages between beta-site covalent transformations and alpha-site activation and deactivation in the tryptophan synthase bienzyme complex

1 reference

12 December 2020

Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60

1 reference

12 December 2020

pH dependence of tryptophan synthase catalytic mechanism: I. The first stage, the beta-elimination reaction

1 reference

12 December 2020

The mechanism of the synthesis of indoleglycerol phosphate catalyzed by tryptophan synthase from Escherichia coli. Steady-state kinetic studies

1 reference

12 December 2020

beta-Site covalent reactions trigger transitions between open and closed conformations of the tryptophan synthase bienzyme complex

1 reference

12 December 2020

Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents

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12 December 2020

Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes

1 reference

12 December 2020

Mechanism of the physiological reaction catalyzed by tryptophan synthase from Escherichia coli.

1 reference

12 December 2020

Allosteric communication in the tryptophan synthase bienzyme complex: roles of the beta-subunit aspartate 305-arginine 141 salt bridge

1 reference

12 December 2020

Channeling of substrates and intermediates in enzyme-catalyzed reactions

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12 December 2020

Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.

1 reference

12 December 2020

Aliphatic alcohols stabilize an alternative conformation of the tryptophan synthase alpha 2 beta 2 complex from Salmonella typhimurium.

1 reference

12 December 2020

10.1007/S00018-009-0028-0

Identifiers

DOI

1 reference

release_aif4g7hfajdr7p5fpexhmbmvvy

5 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/aif4g7hfajdr7p5fpexhmbmvvy

24 November 2022

mapped directly with Wikidata item

PubMed ID

19387555

1 reference

PubMed ID

19387555