(Q34979345)

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Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides

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scholarly article

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Europe PubMed Central

5 August 2017

Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides (English)

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Europe PubMed Central

5 August 2017

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Joan-Emma Shea

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Europe PubMed Central

5 August 2017

publication date

29 August 2013

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Europe PubMed Central

5 August 2017

PLOS Computational Biology

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Europe PubMed Central

5 August 2017

9

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Europe PubMed Central

5 August 2017

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Europe PubMed Central

5 August 2017

e1003211

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Europe PubMed Central

5 August 2017

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Creative Commons Attribution 4.0 International

29 August 2013

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April 2022 Public Data File from Crossref

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The effect of Aβ on IAPP aggregation in the presence of an isolated β-cell membrane

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Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20

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2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure

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Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

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The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces

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On the origins of the weak folding cooperativity of a designed ββα ultrafast protein FSD-1.

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β-Barrel topology of Alzheimer's β-amyloid ion channels

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8 July 2018

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Combination of kinetically selected inhibitors in trans leads to highly effective inhibition of amyloid formation

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8 July 2018

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

1 reference

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8 July 2018

The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.

1 reference

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8 July 2018

Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity.

1 reference

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8 July 2018

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

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Unfolded-state dynamics and structure of protein L characterized by simulation and experiment

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8 July 2018

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

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Solution structures of rat amylin peptide: simulation, theory, and experiment

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Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

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The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors

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Oligomers of the prion protein fragment 106-126 are likely assembled from beta-hairpins in solution, and methionine oxidation inhibits assembly without altering the peptide's monomeric conformation

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Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

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Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice

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Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

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Protein folding by zipping and assembly

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Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

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8 July 2018

Direct detection of transient alpha-helical states in islet amyloid polypeptide

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8 July 2018

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

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8 July 2018

Molecular structure of amyloid fibrils: insights from solid-state NMR.

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8 July 2018

Effects of solvent on the structure of the Alzheimer amyloid-beta(25-35) peptide

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Solution structure of amyloid beta-peptide (25-35) in different media

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Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

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Structure of A beta(25-35) peptide in different environments

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1 reference

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1 reference

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

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8 July 2018

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Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.

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Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

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8 July 2018

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8 July 2018

A mechanistic insight into the amyloidogenic structure of hIAPP peptide revealed from sequence analysis and molecular dynamics simulation

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21 January 2018

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

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21 January 2018

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

1 reference

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21 January 2018

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

S20G mutation of the amylin gene is associated with Type II diabetes in Japanese. Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus

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21 January 2018

Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Extensive amyloid formation in transplanted microencapsulated mouse and human islets.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Elucidating the mechanism of lipid membrane-induced IAPP fibrillogenesis and its inhibition by the red wine compound resveratrol: a synchrotron X-ray reflectivity study.

1 reference

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21 January 2018

Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway

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21 January 2018

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

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21 January 2018

Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

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21 January 2018

Conformational dynamics of human IAPP monomers

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21 January 2018

Beta-hairpin conformation of fibrillogenic peptides: structure and alpha-beta transition mechanism revealed by molecular dynamics simulations

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Folding landscapes of the Alzheimer amyloid-beta(12-28) peptide.

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21 January 2018

Structure of the 21-30 fragment of amyloid beta-protein.

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21 January 2018

The structure of the Alzheimer amyloid beta 10-35 peptide probed through replica-exchange molecular dynamics simulations in explicit solvent.

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21 January 2018

Amyloid-beta(29-42) dimer formations studied by a multicanonical-multioverlap molecular dynamics simulation.

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21 January 2018

Structural diversity of dimers of the Alzheimer amyloid-beta(25-35) peptide and polymorphism of the resulting fibrils.

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21 January 2018

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Pramlintide improved glycemic control and reduced weight in patients with type 2 diabetes using basal insulin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Importance of aggregated islet amyloid polypeptide for the progressive beta-cell failure in type 2 diabetes and in transplanted human islets

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Replica-exchange molecular dynamics method for protein folding

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

How accurate are continuum solvation models for drug-like molecules?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Thermodynamics and dynamics of amyloid peptide oligomerization are sequence dependent

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Structure and Thermodynamics of Amylin Dimer Studied by Hamiltonian-Temperature Replica Exchange Molecular Dynamics Simulations

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Comparative Molecular Dynamics Study of Human Islet Amyloid Polypeptide (IAPP) and Rat IAPP Oligomers

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003211

21 January 2018

Widespread amyloid deposition in transplanted human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folding-unfolding thermodynamics of a beta-heptapeptide from equilibrium simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Single-Point Mutation Converts the Highly Amyloidogenic Human Islet Amyloid Polypeptide into a Potent Fibrillization Inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/24009497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PCBI.1003211

1 reference

Europe PubMed Central

5 August 2017

DBLP publication ID

journals/ploscb/WuS13

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

5 August 2017

ResearchGate publication ID

0 references

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