(Q34998538)

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Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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amyotrophic lateral sclerosis

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object named as

Peter Claus

7

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Reinhard Dengler

8

object named as

Reinhard Dengler

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

10

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Susanne Petri

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Nancy Stanslowsky

3

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Nancy Stanslowsky

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Nadine Thau-Habermann

4

object named as

Nadine Thau-Habermann

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

6

object named as

Dongya Huang

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

9

object named as

Martin Stangel

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Hui Sun

1

1 reference

Europe PubMed Central

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5 August 2017

Karelle Bénardais

2

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5 August 2017

Niko Hensel

5

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5 August 2017

language of work or name

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publication date

12 September 2013

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Europe PubMed Central

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5 August 2017

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Europe PubMed Central

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5 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

e72926

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

copyright license

Creative Commons Attribution 4.0 International

12 September 2013

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April 2022 Public Data File from Crossref

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0 references

Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Ablation of proliferating cells in the CNS exacerbates motor neuron disease caused by mutant superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Comparative effects between bone marrow and mesenchymal stem cell transplantation in GDNF expression and motor function recovery in a motorneuron degenerative mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Neuroprotective features of mesenchymal stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Vascular endothelial growth factor attenuates neurodegenerative changes in the NSC-34 motor neuron cell line induced by cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Mesenchymal stromal cells: current understanding and clinical status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Neurotrophic actions of bone marrow stromal cells on primary culture of dorsal root ganglion tissues and neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Analysis of neuroprotective effects of valproic acid on primary motor neurons in monoculture or co-cultures with astrocytes or Schwann cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Effects of P2Y1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Mesenchymal stem cells: a promising candidate in regenerative medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Mesenchymal stem cells: a new strategy for immunosuppression?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Novel cell therapy approaches for brain repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Control of microglial neurotoxicity by the fractalkine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Treatment of neural injury with marrow stromal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

The role of glial reaction and inflammation in Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Adult rat and human bone marrow stromal cells differentiate into neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

8 July 2018

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Immunomodulatory influence of bone marrow-derived mesenchymal stem cells on neuroinflammation in astrocyte cultures

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Bone marrow stromal cells increase astrocyte survival via upregulation of phosphoinositide 3-kinase/threonine protein kinase and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways and stimulate astrocyte trophic f

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Detoxication enzyme inducers modify cytokine production in rat mixed glial cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Production and neuroprotective functions of fractalkine in the central nervous system

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Ciliary neurotrophic factor (CNTF) promotes skeletal muscle progenitor cell (MPC) viability via the phosphatidylinositol 3-kinase-Akt pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

26 October 2018

A review: inflammatory process in Alzheimer's disease, role of cytokines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771979

26 October 2018

Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of CX3CL1

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Expression of nitric oxide synthase isoforms in spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0072926

21 January 2018

Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased cytotoxic potential of microglia from ALS-transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24069165

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0072926

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2013PLoSO...872926S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

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