(Q35002433)

5 August 2017

title

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib (English)

1 reference

5 August 2017

Hideo Takakusa

1

1 reference

5 August 2017

Michelle D Wahlin

2

1 reference

5 August 2017

Chunsheng Zhao

3

1 reference

5 August 2017

Kelsey L Hanson

4

1 reference

5 August 2017

Lee Sun New

5

1 reference

5 August 2017

Eric Chun Yong Chan

6

1 reference

5 August 2017

Sidney D Nelson

7

1 reference

5 August 2017

publication date

1 March 2011

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Drug Metabolism and Disposition

5 August 2017

published in

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5 August 2017

volume

39

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5 August 2017

issue

6

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5 August 2017

page(s)

1022-1030

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Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib

5 August 2017

cites work

1 reference

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8 July 2018

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8 July 2018

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8 July 2018

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Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs

8 July 2018

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Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process

8 July 2018

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Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil

8 July 2018

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Genetic variability in CYP3A5 and its possible consequences.

8 July 2018

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Genetic contribution to variable human CYP3A-mediated metabolism

8 July 2018

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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer

8 July 2018

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An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.

8 July 2018

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In vitro and in vivo drug interactions involving human CYP3A.

8 July 2018

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Drug-mediated inactivation of cytochrome P450.

8 July 2018

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Mechanisms of the Formation and Disposition of Reactive Metabolites That can Cause Acute Liver Injury

8 July 2018

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

8 July 2018

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A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis

8 July 2018

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Cytochrome P-450 ligands: metyrapone revisited.

8 July 2018

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Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

8 July 2018

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Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

8 July 2018

1 reference

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Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

8 July 2018

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Cytochrome P-455 complex formation in the metabolism of phenylalkylamines--IV. Spectral evidences for metabolic conversion of methamphetamine to N-hydroxyamphetamine

8 July 2018

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Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer

8 July 2018

1 reference

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Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100900

Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100900

Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100900

Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100900

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

26 October 2018

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Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

26 October 2018

1 reference

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Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A

26 October 2018

1 reference

12 December 2020

Nitrosoalkanes as Fe(II) ligands in the 455-nm-absorbing cytochrome P-450 complexes formed from nitroalkanes in reducing conditions

1 reference

12 December 2020

Ticrynafen-associated hepatic injury: analysis of 340 cases

1 reference

12 December 2020

Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9

1 reference

12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

12 December 2020

Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.110.037531

1 reference

5 August 2017

1 reference

5 August 2017

1 reference