(Q35010454)

5 August 2017

title

NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production (English)

1 reference

5 August 2017

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Karina R Bortoluci

9

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author name string

Virginia M Gonçalves

1

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5 August 2017

Kely C Matteucci

2

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5 August 2017

Carina L Buzzo

3

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5 August 2017

Bruna H Miollo

4

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5 August 2017

Danny Ferrante

5

1 reference

5 August 2017

Ana C Torrecilhas

6

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5 August 2017

Mauricio M Rodrigues

7

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5 August 2017

Jose M Alvarez

8

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5 August 2017

language of work or name

English

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publication date

3 October 2013

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PLoS Neglected Tropical Diseases

5 August 2017

published in

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5 August 2017

volume

7

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5 August 2017

issue

10

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5 August 2017

page(s)

e2469

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Creative Commons Attribution 2.5 Generic

5 August 2017

copyright license

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on focus list of Wikimedia project

ScienceSource

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cites work

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8 July 2018

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8 July 2018

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8 July 2018

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Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi

8 July 2018

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8 July 2018

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The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

8 July 2018

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A novel pathway for inducible nitric-oxide synthase activation through inflammasomes

8 July 2018

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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

8 July 2018

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Molecular mechanism of NLRP3 inflammasome activation

8 July 2018

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Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development

8 July 2018

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Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

8 July 2018

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

8 July 2018

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

8 July 2018

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8 July 2018

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Control of infection by pyroptosis and autophagy: role of TLR and NLR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Critical functions of priming and lysosomal damage for NLRP3 activation

8 July 2018

1 reference

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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

8 July 2018

1 reference

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The inflammasomes: mechanisms of activation and function

8 July 2018

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Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.

8 July 2018

1 reference

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Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

The effects of nitric oxide on the immune system during Trypanosoma cruzi infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Malarial hemozoin is a Nalp3 inflammasome activating danger signal

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Chagas disease in Spain, the United States and other non-endemic countries

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Inflammasome recognition of influenza virus is essential for adaptive immune responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Role of endogenous IFN-gamma in macrophage programming induced by IL-12 and IL-18.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Cryopyrin activates the inflammasome in response to toxins and ATP

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Interleukin-12 but not interleukin-18 is required for immunity to Trypanosoma cruzi in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Chagas disease: a new worldwide challenge.

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Role of nitric oxide in resistance and histopathology during experimental infection with Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin

26 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002469

Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789781

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24098823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PNTD.0002469

1 reference

5 August 2017

1 reference

5 August 2017

1 reference