(Q35014902)

5 August 2017

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title

The multiple functions of Numb (English)

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5 August 2017

Alberto Gulino

1

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5 August 2017

Lucia Di Marcotullio

series ordinal

2

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5 August 2017

Isabella Screpanti

series ordinal

3

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5 August 2017

language of work or name

English

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publication date

26 November 2009

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Experimental Cell Research

5 August 2017

published in

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5 August 2017

volume

316

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5 August 2017

issue

6

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5 August 2017

page(s)

900-906

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numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

A switch in numb isoforms is a critical step in cortical development.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Mouse numb is an essential gene involved in cortical neurogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Multiple roles of mouse Numb in tuning developmental cell fates.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Murine numb regulates granule cell maturation in the cerebellum

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

NUMB controls p53 tumour suppressor activity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Siah-1 binds and regulates the function of Numb

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb regulates post-endocytic trafficking and degradation of Notch1.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb is an endocytic protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Mechanisms of asymmetric stem cell division

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Stem cells, cancer, and cancer stem cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Hedgehog signaling in development and cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

p53 suppresses the self-renewal of adult neural stem cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Notch signalling regulates stem cell numbers in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

High levels of Notch signaling down-regulate Numb and Numblike

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.11.017

10.1016/J.YEXCR.2009.11.017

7 January 2021

Identifiers

DOI

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5 August 2017

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