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ACAT inhibitors: the search for a novel and effective treatment of hypercholesterolemia and atherosclerosis.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
ACAT inhibitors: the search for a novel and effective treatment of hypercholesterolemia and atherosclerosis
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
main subject
hypercholesterolemia
0 references
author name string
Drago R Sliskovic
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
Joseph A Picard
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
Brian R Krause
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
publication date
1 January 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
published in
Progress in medicinal chemistry
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
volume
39
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
page(s)
121-171
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
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7 January 2021
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7 January 2021
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ACAT inhibitors as antiatherosclerotic agents: compounds and mechanisms
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7 January 2021
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Acyl-coenzyme A:cholesterol acyltransferase
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7 January 2021
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Cholesterol ester metabolism
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7 January 2021
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Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-CoA: cholesterol acyltransferase activity in rabbit intestinal microsomes
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7 January 2021
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Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolase
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7 January 2021
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Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice
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Crossref
reference URL
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7 January 2021
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Postprandial hyperlipidemia in streptozotocin-induced diabetic rats is due to abnormal increase in intestinal acyl coenzyme A:cholesterol acyltransferase activity
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
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7 January 2021
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On the mechanism for the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, of cholesterol 7alpha-hydroxylase and of acyl-coenzyme A:cholesterol acyltransferase by free cholesterol
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7 January 2021
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Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool
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7 January 2021
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Cholesteryl ester metabolism in liver and blood plasma of various animal species.
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7 January 2021
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Acyl-coenzyme A:cholesterol acyltransferase in human liver. In vitro detection and some characteristics of the enzyme.
1 reference
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7 January 2021
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Hepatic acyl-CoA:cholesterol acyltransferase. Development of a standard assay and determination in patients with cholesterol gallstones
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Crossref
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7 January 2021
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Influence of Duration of Cholesterol Feeding on Esterification of Fatty Acids by Cell-Free Preparation of Pigeon Aorta
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7 January 2021
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Properties of acyl-CoA:cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits
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7 January 2021
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Studies of the mechanism of augmented synthesis of cholesteryl ester in atherosclerotic rabbit aortic microsomes
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7 January 2021
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Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis
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7 January 2021
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inferred from DOI database lookup
Inhibition of acyl coenzyme A: Cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Bile acid synthesis in hamster hepatocytes in primary culture: sources of cholesterol and comparison with other species
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells
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7 January 2021
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Acyl coenzyme A: cholesterol acyltransferase inhibition and hepatic apolipoprotein B secretion
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Esterification of cholesterol by subcellular fractions from swine arteries, and inhibition by amphipathic and polyanionic compounds
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of cholesterol esterification in macrophages and vascular smooth muscle foam cells: evaluation of E5324, an acyl-CoA cholesterol acyltransferase inhibitor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel effects of the acyl-coenzyme A:Cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translocation of ricin A-chain into proteoliposomes reconstituted from Golgi and endoplasmic reticulum.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of the acyl-CoA:cholesterol O-acyltransferase inhibitor, CL 277082, on cholesteryl ester accumulation in rabbit macrophage-rich granulomas and hepatic tissue
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sterol esterification in yeast: a two-gene process
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disposition of a silicon-containing amide, an inhibitor of acyl-CoA: cholesterol acyltransferase, in dog and rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of acylcoenzyme A: cholesterol acyltransferase activity by PD128O42: effect on cholesterol metabolism and secretion in CaCo-2 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subacute toxicity of a novel inhibitor of acyl-CoA: cholesterol acyltransferase in beagle dogs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphogenesis of a zone-specific adrenocortical cytotoxicity in guinea pigs administered PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATP depletion is associated with cytotoxicity of a novel lipid regulator in guinea pig adrenocortical cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatic and Adrenal Toxicity of a Novel Lipid Regulator in Beagle Dogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Difference between normal and WHHL rabbits in susceptibility to the adrenal toxicity of an acyl-CoA:cholesterol acyltransferase inhibitor, FR145237
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mesenteric lymph node hemangiomas of Wistar rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of HL-004, a novel ACAT inhibitor, on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypolipidemic and antiatherosclerotic effects of a novel ACAT inhibitor, HL-004, in stroke-prone spontaneously hypertensive rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ACAT inhibitor HL-004 inhibits cholesterol absorption and lowers serum cholesterol in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological profile of F 12511, (S)-2',3', 5'-trimethyl-4'-hydroxy-alpha-dodecylthioacetanilide a powerful and systemic acylcoenzyme A: cholesterol acyltransferase inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potent Inhibitors of Acyl-CoA:Cholesterol Acyltransferase. Structure-Activity Relationships of Novel N-(4-Oxo-8-chromanyl) amides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). Part 1: identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitory effect of a new ureidophenol derivative T-2591 on LDL oxidation and ACAT activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FCE 27677: a novel inhibitor of acyl-CoA: cholesterol acyltransferase with potent oral hypolipidemic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Syntheses and pharmacological activities of novel optically active inhibitors of acyl-CoA: cholesterol O-acyltransferase: EAB-309 ((R)-N-2-(1,3-benzodioxol-4-yl)heptyl-N'-2,6-diisopropylphenylurea) and its enantiomer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A selective inhibitor of intestinal ACAT, EAB309 suppresses both intestinal and hepatic cholesterol output and stimulates chylomicron removal
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetic properties of YM17E, an inhibitor of acyl coenzyme A: cholesterol acyl transferase, and serum cholesterol levels in healthy volunteers.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of NTE-122, an acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and lipid secretion from CaCo-2 cells, and cholesterol absorption in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitory Effects and Enzyme Selectivity of F-1394, a Pantotheic Acid Derivative
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: possible role of hepatic ACAT in very low density lipoprot
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 11. Structure-activity relationships of several series of compounds derived from N-(chlorocarbonyl) isocyanate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New cyclodepsipeptides, enniatins D, E and F produced by Fusarium sp. FO-1305
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. II. Structure elucidation of purpactins A, B and C
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AS-186 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Penicillium asperosporum KY1635
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glisoprenins, new inhibitors of acyl-CoA: Cholesterol acyltransferase produced by Gliocladium sp. FO-1513. I. Production, isolation and physico-chemical and biological properties.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acaterin, a novel inhibitor of acyl-CoA: Cholesterol acyltransferase produced by Pseudomonas sp. A92.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Terpendoles, Novel ACAT Inhibitors Produced by Albophoma yamanashiensis. III. Production, Isolation and Structure Elucidation of New Components
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gypsetin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. I. Fermentation, isolation, physico-chemical properties and biological activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pyripyropenes, Novel ACAT inhibitors produced by Aspergillus fumigatus. III. Structure elucidation of pyripyropenes E to L
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus. IV. Structure elucidation of pyripyropenes M to R
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GERI-BP001, a new inhibitor of acyl-CoA: Cholesterol acyltransferase produced by Aspergillus fumigatus F37
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GERI-BP001 Compounds, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase from Aspergillus fumigatus F37. I. Production, Isolation, and Physico-chemical and Biological Properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GERI-BP002-A, novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus F93
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemical modification and structure-activity relationships of pyripyropenes. 1. Modification at the four hydroxyl groups
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemical modification and structure-activity relationships of pyripyropenes. 2. 1,11-Cyclic analogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Triterpenoid saponins from Ilex kudincha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-CoA:Cholesterol Acyltransferase Inhibitory Activity of Lignans Isolated fromSchizandra, Machilus and MagnoliaSpecies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two new monoterpene glycosides from ku-ding-cha. Inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of acyl-CoA:cholesterol acyltransferase by a traditional herbal medicine (Kampo medicine), Ogi-Keishi-Gomotsu-To-Ka-Kojin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypocholesterolemic properties of plant indoles. Inhibition of acyl-CoA:cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassicin derivatives
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol-esterifying activity of aortas from atherosclerosis-resistant and atherosclerosis-susceptible species.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970070-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0079-6468(08)70070-5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
PubMed publication ID
12536672
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12536672
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12536672%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
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