(Q35062454)

6 August 2017

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title

Telomeres and cancer: a tale with many endings (English)

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6 August 2017

María A Blasco

1

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language of work or name

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1 February 2003

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Current Opinion in Genetics & Development

6 August 2017

published in

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6 August 2017

volume

13

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6 August 2017

issue

1

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6 August 2017

page(s)

70-76

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Switching and signaling at the telomere

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Protection of mammalian telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Mammalian telomeres end in a large duplex loop

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Many ways to telomere dysfunction: in vivo studies using mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomerase in the human organism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Putting the stress on senescence

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Clinical utility of telomerase in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Different telomere damage signaling pathways in human and mouse cells

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

DNA-PKcs is critical for telomere capping

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Strand-Specific Postreplicative Processing of Mammalian Telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Deletion of Ku86 causes early onset of senescence in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Senescence Induced by Altered Telomere State, Not Telomere Loss

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Control of human telomere length by TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Constitutive telomerase expression promotes mammary carcinomas in aging mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomerase beyond telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Telomerase inhibition, oligonucleotides, and clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

A highly selective telomerase inhibitor limiting human cancer cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

Alternative lengthening of telomeres in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900011-4

7 January 2021

10.1016/S0959-437X(02)00011-4

Identifiers

DOI

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6 August 2017

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