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Putting the stress on senescence
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Putting the stress on senescence
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
author
Manuel Serrano
1 reference
stated in
ORCID Public Data File 2021
author name string
Serrano M
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
Blasco MA
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
publication date
1 December 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
published in
Current Opinion in Cell Biology
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
volume
13
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
page(s)
748-753
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
issue
6
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
cites work
How and why we age.
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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The role of senescence and immortalization in carcinogenesis
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro
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Crossref
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Telomeres and telomerase
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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Benefits of bad telomeres
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7 January 2021
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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
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Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
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Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
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7 January 2021
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Extension of life-span by introduction of telomerase into normal human cells
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7 January 2021
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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
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https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
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https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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New link in a web of human genes
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.
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reference URL
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7 January 2021
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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
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7 January 2021
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Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells
1 reference
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reference URL
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7 January 2021
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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Tumor suppressors and oncogenes in cellular senescence.
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Genetic and epigenetic changes in human epithelial cells immortalized by telomerase
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Crossref
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https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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p19ARF links the tumour suppressor p53 to Ras
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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inferred from DOI database lookup
Escape from premature senescence is not sufficient for oncogenic transformation by Ras.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence of human fibroblasts induced by oncogenic Raf.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
JunD protects cells from p53-dependent senescence and apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Atmospheric carbon dioxide concentrations over the past 60 million years
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Cellular senescence as a tumor-protection mechanism: the essential role of counting
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanisms of the biological clock in cultured fibroblasts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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A biomarker that identifies senescent human cells in culture and in aging skin in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
1 reference
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reference URL
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7 January 2021
based on heuristic
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Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of p14(ARF) in replicative and induced senescence of human fibroblasts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
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Lack of replicative senescence in cultured rat oligodendrocyte precursor cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of replicative senescence in normal rodent glia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900278-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0955-0674(00)00278-7
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
PubMed ID
11698192
1 reference
stated in
Europe PubMed Central
PubMed ID
11698192
retrieved
2 August 2017
ResearchGate publication ID
11656662
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