(Q35071380)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24350845%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition (English)

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3 March 2020

5

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3 March 2020

1

I A Schepetkin

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3 March 2020

author name string

A I Khlebnikov

2

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3 March 2020

M P Giovannoni

3

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3 March 2020

L N Kirpotina

4

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3 March 2020

M T Quinn

6

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3 March 2020

publication date

1 January 2014

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Current Medicinal Chemistry

3 March 2020

published in

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3 March 2020

volume

21

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3 March 2020

issue

13

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3 March 2020

page(s)

1478-1504

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T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor.

3 March 2020

cites work

1 reference

12 December 2020

The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infection

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12 December 2020

Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells

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12 December 2020

Receptor-directed inhibition of chemotactic factor-induced neutrophil hyperactivity by pyrazolon derivatives. Definition of a chemotactic peptide antagonist

1 reference

12 December 2020

Computational structure-activity relationship analysis of small-molecule agonists for human formyl peptide receptors.

1 reference

12 December 2020

Receptor-based pharmacophore and pharmacophore key descriptors for virtual screening and QSAR modeling

1 reference

12 December 2020

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition.

1 reference

12 December 2020

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

1 reference

12 December 2020

Computational drug discovery

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12 December 2020

Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice

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12 December 2020

The pyrazolone originally reported to be a formyl peptide receptor (FPR) 2/ALX-selective agonist is instead an FPR1 and FPR2/ALX dual agonist

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12 December 2020

Demonstration of a receptor on rabbit neutrophils for chemotactic peptides

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12 December 2020

Homology model-assisted elucidation of binding sites in GPCRs.

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12 December 2020

A G protein-coupled receptor responsive to bile acids

1 reference

12 December 2020

The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells

1 reference

12 December 2020

The interaction of 3,5-pyrazolidinedione drugs with receptors for f-Met-Leu-Phe on human neutrophil leukocytes: a study of the structure–activity relationship

1 reference

12 December 2020

T21/DP107, A synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G-protein-coupled formyl peptide receptors

1 reference

12 December 2020

Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation

1 reference

12 December 2020

P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring

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12 December 2020

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12 December 2020

Formyl peptide receptor-like 1 mediated endogenous TRAIL gene expression with tumoricidal activity

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12 December 2020

Chemotactic peptide-induced acute colitis in rabbits

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12 December 2020

Formyl-methionyl-leucyl-phenylalanine causes bronchoconstriction in rabbits.

1 reference

12 December 2020

A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand

1 reference

12 December 2020

Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury

1 reference

12 December 2020

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1

1 reference

12 December 2020

Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis.

1 reference

12 December 2020

Discovery of pyrazoles as novel FPR1 antagonists

1 reference

12 December 2020

Identification of a nuclear receptor for bile acids

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12 December 2020

Endotoxin augments hemodynamic and metabolic effects of formyl-methionyl-leucyl-phenylalanine (FMLP) in rabbits

1 reference

12 December 2020

Synthesis, HPLC enantioresolution, and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) agonists.

1 reference

12 December 2020

Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1(2-26).

1 reference

12 December 2020

Haematological effects of inhalation of N-formyl-methionyl-leucyl-phenylalanine in man.

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12 December 2020

Optimal neighbor selection in molecular similarity: comparison of arbitrary versus tailored prediction spaces

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12 December 2020

N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation

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12 December 2020

Transient receptor potential V2 expressed in sensory neurons is activated by probenecid

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12 December 2020

Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system.

1 reference

12 December 2020

Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils

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12 December 2020

Modeling G protein-coupled receptors and their interactions with ligands

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12 December 2020

The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations

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12 December 2020

Pharmacophore modeling methods in focused library selection - applications in the context of a new classification scheme

1 reference

12 December 2020

Formyl peptide receptors from immune and vomeronasal system exhibit distinct agonist properties

1 reference

12 December 2020

Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides.

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12 December 2020

Enrichment factor analyses on G-protein coupled receptors with known crystal structure.

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12 December 2020

Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide receptors

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12 December 2020

Extraction of structure-activity relationship information from high-throughput screening data

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12 December 2020

A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu

1 reference

12 December 2020

Neutrophil targeting heterobivalent SPECT imaging probe: cFLFLF-PEG-TKPPR-99mTc

1 reference

12 December 2020

Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites

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12 December 2020

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis.

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12 December 2020

The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1.

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12 December 2020

Phospholipase C in Living Cells

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12 December 2020

The ligand binding site of the formyl peptide receptor maps in the transmembrane region

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12 December 2020

Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1.

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12 December 2020

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins.

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12 December 2020

Acute colitis produced by chemotactic peptides in rats and mice

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12 December 2020

Chemotactic peptides. Mechanisms, functions, and possible role in inflammatory bowel disease

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12 December 2020

TRPA1 agonist activity of probenecid desensitizes channel responses: consequences for screening.

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12 December 2020

Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ

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12 December 2020

High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues

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12 December 2020

Customizing G Protein-coupled receptor models for structure-based virtual screening

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12 December 2020

Rationalizing the activities of diverse cholecystokinin 2 receptor antagonists using molecular field points.

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12 December 2020

Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils

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12 December 2020

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

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12 December 2020

G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma

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12 December 2020

Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells

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12 December 2020

V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

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12 December 2020

Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library

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12 December 2020

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

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12 December 2020

Ligand-steered modeling and docking: A benchmarking study in class A G-protein-coupled receptors

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12 December 2020

Pleiotropic roles of formyl peptide receptors

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12 December 2020

Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants

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12 December 2020

Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils

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12 December 2020

Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors

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12 December 2020

Increased neutrophil receptors for and response to the proinflammatory bacterial peptide formyl-methionyl-leucyl-phenylalanine in Crohn's disease.

1 reference

12 December 2020

Molecular field technology applied to virtual screening and finding the bioactive conformation

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12 December 2020

The selection and design of GPCR ligands: from concept to the clinic

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12 December 2020

Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia.

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12 December 2020

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄.

1 reference

12 December 2020

Leukocyte chemoattractant receptor FPR2 may accelerate atherogenesis

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12 December 2020

The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1.

1 reference

12 December 2020

Calpain inhibitors stimulate phagocyte functions via activation of human formyl peptide receptors

1 reference

12 December 2020

Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains

1 reference

12 December 2020

The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vit

1 reference

12 December 2020

Peptide derivatives as agonists or antagonists of formylpeptide receptors: analysis of their effects on neutrophils

1 reference

12 December 2020

Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

1 reference

12 December 2020

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.

1 reference

12 December 2020

Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease

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12 December 2020

Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-alpha production.

1 reference

12 December 2020

Molecular modeling and simulation of membrane lipid-mediated effects on GPCRs

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12 December 2020

Functional characterization of three mouse formyl peptide receptors

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12 December 2020

Host defense peptides for use as potential therapeutics.

1 reference

12 December 2020

C- and N-terminal residue effect on peptide derivatives' antagonism toward the formyl-peptide receptor

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12 December 2020

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment

1 reference

12 December 2020

Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia-reperfusion injury?

1 reference

12 December 2020

Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor.

1 reference

12 December 2020

Genetic ablation of the fpr1 gene confers protection from smoking-induced lung emphysema in mice.

1 reference

12 December 2020

Flow cytometric measurement of calcium influx in murine T cell hybrids using Fluo-3 and an organic-anion transport inhibitor

1 reference

12 December 2020

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family

1 reference

12 December 2020

6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors

1 reference

12 December 2020

Identification of a compound that directly stimulates phospholipase C activity

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12 December 2020

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

1 reference

12 December 2020

Structure-activity relationship of for-L-Met L-Leu-L-Phe-OMe analogues in human neutrophils

1 reference

12 December 2020

Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation

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12 December 2020

Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform

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12 December 2020

What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4?

1 reference

12 December 2020

Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation

1 reference

12 December 2020

Lead optimisation of pyrazoles as novel FPR1 antagonists

1 reference

12 December 2020

Formylated chemotactic peptides can mimic the secondary, provoking endotoxin injection in the generalized Shwartzman reaction

1 reference

12 December 2020

Effects of synthetic peptides on the inflammatory response and their therapeutic potential

1 reference

12 December 2020

Intravascular danger signals guide neutrophils to sites of sterile inflammation

1 reference

12 December 2020

Airway activation of formyl peptide receptors inhibits Th1 and Th17 cell responses via inhibition of mediator release from immune and inflammatory cells and maturation of dendritic cells

1 reference

12 December 2020

Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription

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12 December 2020

High content pharmacophores from molecular fields: a biologically relevant method for comparing and understanding ligands

1 reference

12 December 2020

Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells.

1 reference

12 December 2020

Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor

1 reference

12 December 2020

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

1 reference

12 December 2020

Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches

1 reference

12 December 2020

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

1 reference

12 December 2020

High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands

1 reference

12 December 2020

Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.

1 reference

12 December 2020

Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes

1 reference

12 December 2020

Ligand-optimized homology models of D₁ and D₂ dopamine receptors: application for virtual screening

1 reference

12 December 2020

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

1 reference

12 December 2020

Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation

1 reference

12 December 2020

Formyl-peptide receptors revisited

1 reference

12 December 2020

Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

1 reference

12 December 2020

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2

1 reference

12 December 2020

Losartan, a selective inhibitor of subtype AT1 receptors for angiotensin II, inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors

1 reference

12 December 2020

Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin

1 reference

12 December 2020

Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging

1 reference

12 December 2020

Formyl peptide receptor 1 and 2 dual agonist inhibits human neutrophil chemotaxis by the induction of chemoattractant receptor cross-desensitization.

1 reference

12 December 2020

Discovery of small molecule human FPR1 receptor antagonists

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12 December 2020

Inhibitory effect of Crotalus durissus terrificus venom on chronic edema induced by injection of bacillus Calmette-Guérin into the footpad of mice.

1 reference

12 December 2020

High-content screening: flow cytometry analysis

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12 December 2020

Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.

1 reference

12 December 2020

Molecular biology for formyl peptide receptors in human diseases

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12 December 2020

High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists

1 reference

12 December 2020

Effects of tenoxicam on superoxide anion formation, β-glucuronidase release and fMLP binding in human neutrophils: Comparison with other NSAIDs

1 reference

12 December 2020

Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.

1 reference

12 December 2020

Granulocyte function is stimulated by a novel hexapeptide, WKYMVm, in chemotherapy-treated cancer patients.

1 reference

12 December 2020

Stimulation of inflammatory mediators secretion by chemotactic peptides in rat colitis model

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12 December 2020

Distinct signaling cascades elicited by different formyl peptide receptor 2 (FPR2) agonists

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12 December 2020

Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses

1 reference

12 December 2020

A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1.

1 reference

12 December 2020

Pharmacophore model for bile acids recognition by the FPR receptor

1 reference

12 December 2020

Structure-activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: a simplified approach using atom pair descriptors

1 reference

12 December 2020

Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease.

1 reference

12 December 2020

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation

1 reference

12 December 2020

A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects

1 reference

12 December 2020

A novel nonpeptide ligand for formyl peptide receptor-like 1.

1 reference

12 December 2020

G Protein-Coupled Receptors: target-based in silico screening

1 reference

12 December 2020

Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production.

1 reference

12 December 2020

Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists

1 reference

12 December 2020

N-formylmethionyl peptides as chemoattractants for leucocytes

1 reference

12 December 2020

Annexin-1 modulates repair of gastric mucosal injury

1 reference

12 December 2020

Selective inhibition of N-formylpeptide-induced neutrophil activation by carbamate-modified peptide analogues

1 reference

12 December 2020

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.

1 reference

12 December 2020

Phagocytosis of apoptotic cells and the resolution of inflammation

1 reference

12 December 2020

Molecular field extrema as descriptors of biological activity: definition and validation.

1 reference

12 December 2020

The annexin I sequence gln(9)-ala(10)-trp(11)-phe(12) is a core structure for interaction with the formyl peptide receptor 1.

1 reference

12 December 2020

Role of formyl peptide receptors (FPR) in abnormal inflammation responses involved in neurodegenerative diseases

1 reference

12 December 2020

Sulfasalazine inhibition of binding of N-formyl-methionyl-leucyl-phenylalanine (FMLP) to its receptor on human neutrophils

1 reference

12 December 2020

Inhibition of neutrophil migration in mice by mouse formyl peptide receptors 1 and 2 dual agonist: indication of cross-desensitization in vivo

1 reference

12 December 2020

LigSeeSVM: ligand-based virtual screening using support vector machines and data fusion

1 reference

12 December 2020

Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist.

1 reference

12 December 2020

Hemodynamic and metabolic effects of intravenous formyl-methionyl-leucyl-phenylalanine (FMLP) in rabbits.

1 reference

12 December 2020

Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries

1 reference

12 December 2020

Characterization of the Binding Site on the Formyl Peptide Receptor Using Three Receptor Mutants and Analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu

1 reference

12 December 2020

Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists

1 reference

12 December 2020

10.2174/0929867321666131218095521

Identifiers

DOI

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3 March 2020

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3 March 2020

1 reference

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