(Q35076704)

6 August 2017

1 reference

title

Kinetic perspectives of T cell antigen receptor signaling. A two-tier model for T cell full activation (English)

1 reference

6 August 2017

Makio Iwashima

1

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6 August 2017

publication date

1 February 2003

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6 August 2017

published in

Immunological Reviews

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6 August 2017

volume

191

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6 August 2017

page(s)

196-210

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T cell receptor antagonists and partial agonists

6 August 2017

cites work

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

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T cell antigen receptor signal transduction

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

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Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

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Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

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The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.

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The role of adapter proteins in T cell activation

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Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

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Positive and negative regulation of T-cell activation by adaptor proteins

21 January 2018

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Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap

21 January 2018

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Scaffolds, adaptors and linkers of TCR signaling: theory and practice

21 January 2018

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Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

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Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

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Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

21 January 2018

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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

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Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

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Selective modulation of protein kinase C-theta during T-cell activation

21 January 2018

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Partners in transcription: NFAT and AP-1.

21 January 2018

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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Calcium signalling--an overview

21 January 2018

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Transcription factors of the NFAT family: regulation and function

21 January 2018

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Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

21 January 2018

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Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity.

21 January 2018

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The regulation of AP-1 activity by mitogen-activated protein kinases

21 January 2018

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

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JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

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CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

21 January 2018

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CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites

21 January 2018

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Protein kinase Ctheta: a new essential superstar on the T-cell stage

21 January 2018

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A requirement for CARMA1 in TCR-induced NF-kappa B activation

21 January 2018

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Missing pieces in the NF-kappaB puzzle

21 January 2018

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It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.

21 January 2018

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

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Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

21 January 2018

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Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

21 January 2018

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

21 January 2018

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Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

21 January 2018

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Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

21 January 2018

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Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3

21 January 2018

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Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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Positive selection through a motif in the alphabeta T cell receptor

21 January 2018

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Characterization of antigen receptor response elements within the interleukin-2 enhancer

21 January 2018

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Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells

21 January 2018

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Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

21 January 2018

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The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain

21 January 2018

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Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes

21 January 2018

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IkappaB family members function by different mechanisms

21 January 2018

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

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Not all Shc's roads lead to Ras

21 January 2018

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Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

21 January 2018

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Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts

21 January 2018

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Signaling via Shc family adapter proteins

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Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression

21 January 2018

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Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins

21 January 2018

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cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

21 January 2018

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Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain

21 January 2018

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Functions of newly identified members of the tumor necrosis factor receptor/ligand superfamilies in lymphocytes

21 January 2018

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The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription

21 January 2018

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Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

21 January 2018

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Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics

21 January 2018

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The immunological synapse.

21 January 2018

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T cell receptor signaling precedes immunological synapse formation

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

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Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features.

21 January 2018

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An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

21 January 2018

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Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action

21 January 2018

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Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

21 January 2018

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The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

21 January 2018

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Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation

21 January 2018

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T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex

21 January 2018

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T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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Tumor Necrosis Factor-α Activation of NF-κB Requires the Phosphorylation of Ser-471 in the Transactivation Domain of c-Rel

21 January 2018

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Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

21 January 2018

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7 January 2021

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

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7 January 2021

From TCR Engagement to T Cell Activation

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7 January 2021

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells

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7 January 2021

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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7 January 2021

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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7 January 2021

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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7 January 2021

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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7 January 2021

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

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7 January 2021

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

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7 January 2021

NFAT signaling: choreographing the social lives of cells

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7 January 2021

Cytokines, virokines and the evolution of immunity

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7 January 2021

Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Calcineurin: From structure to function

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

NFATc1 and NFATc2 together control both T and B cell activation and differentiation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

The transcription factor NFAT4 is involved in the generation and survival of T cells

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Rapid targeting of nuclear proteins to the cytoplasm

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1

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7 January 2021

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

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7 January 2021

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

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7 January 2021

Corepression of RelA and c-rel inhibits immunoglobulin kappa gene transcription and rearrangement in precursor B lymphocytes.

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7 January 2021

Early signal transduction by the antigen receptor without commitment to T cell activation

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7 January 2021

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

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7 January 2021

PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection

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7 January 2021

Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation

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7 January 2021

Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells

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7 January 2021

B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1

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7 January 2021

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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7 January 2021

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

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7 January 2021

Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation

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7 January 2021

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

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7 January 2021

Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor

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7 January 2021

A nonredundant role for the adapter protein Shc in thymic T cell development

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Interleukin 2 receptor gene expression in normal human T lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

CD4 augments the response of a T cell to agonist but not to antagonist ligands

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Molecular regulation of the IL-2 gene: rheostatic control of the immune system

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Development of chronic colitis is dependent on the cytokine MIF

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00024.X

7 January 2021

10.1034/J.1600-065X.2003.00024.X

Identifiers

DOI

1 reference

6 August 2017

1 reference