Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q35078774)
Watch
English
Disrupting TP53 in mouse models of human cancers
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Disrupting TP53 in mouse models of human cancers
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
author name string
John M Parant
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
Guillermina Lozano
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
publication date
1 March 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
published in
Human Mutation
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
volume
21
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
page(s)
321-326
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
cites work
Post-translational modifications and activation of p53 by genotoxic stresses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of p53 in tumour suppression: lessons from mouse models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role for oncogenic Ras in tumour maintenance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gain of function mutations in p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of genetic background on tumorigenesis in p53-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Li-Fraumeni syndrome: an inherited susceptibility to cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversible tumorigenesis by MYC in hematopoietic lineages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presence of a potent transcription activating sequence in the p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor spectrum analysis in p53-mutant mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MdmX protects p53 from Mdm2-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A transactivation-deficient mouse model provides insights into Trp53 regulation and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53: puzzle and paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High metastatic potential in mice inheriting a targeted p53 missense mutation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 status and the efficacy of cancer therapy in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse models dissect the role of p53 in cancer and development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
myc function and regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 and Mdm2 families in cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis suppresses tumor growth and progression in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer modeling in the modern era: progress and challenges
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of mouse p53 Ser23 and the response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ons and offs of inducible transgenic technology: a review.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHUMU.10186
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/HUMU.10186
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
PubMed ID
12619119
1 reference
stated in
Europe PubMed Central
PubMed ID
12619119
retrieved
6 August 2017
ResearchGate publication ID
10871996
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit