(Q35081538)

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Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease

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Europe PubMed Central

PubMed publication ID

6 August 2017

Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

steatohepatitis

0 references

alcoholic liver disease

1 reference

based on heuristic

inferred from title

6

object named as

Silvia Balbo

0 references

Stephen S. Hecht

object named as

Stephen Hecht

10

0 references

author name string

Valerie Zabala

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Ming Tong

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Rosa Yu

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Teresa Ramirez

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Emine B Yalcin

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Elizabeth Silbermann

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Chetram Deochand

8

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Kavin Nunez

9

1 reference

Europe PubMed Central

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6 August 2017

Suzanne M de la Monte

11

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6 August 2017

language of work or name

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publication date

24 January 2015

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6 August 2017

Alcohol and Alcoholism

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Europe PubMed Central

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6 August 2017

50

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Europe PubMed Central

PubMed publication ID

6 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

118-131

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Europe PubMed Central

PubMed publication ID

6 August 2017

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

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Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin

1 reference

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8 July 2018

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

1 reference

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Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse

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Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitis

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Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis

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The emerging role of autophagy in alcoholic liver disease.

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8 July 2018

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach

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Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease

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Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease

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Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke

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Acetaldehyde and gastric cancer

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Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines

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Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease

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8 July 2018

Endoplasmic reticulum stress in liver disease

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Histopathological evaluation of fatty and alcoholic liver diseases

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Diagnosis and management of alcoholic liver disease

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Pathogenesis of alcoholic liver disease: interactions between parenchymal and non-parenchymal cells

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8 July 2018

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

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Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance

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8 July 2018

Formation of acetaldehyde-derived DNA adducts due to alcohol exposure

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Hepatocellular ballooning in NASH.

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Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease

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8 July 2018

Early limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabetes and neurodegeneration

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Alcoholic liver disease-related mortality in the United States: 1980-2003.

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The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat

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8 July 2018

Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment

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Alcoholic liver disease.

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The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids

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PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair

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Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

1 reference

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Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake

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Molecular mechanisms of alcoholic fatty liver

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N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis

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Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

1 reference

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Insulin resistance in experimental alcohol-induced liver disease

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Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver

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Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway

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Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry

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Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition

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p16INK4a and beta-catenin alterations in rat liver tumors induced by NNK.

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Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain

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8 July 2018

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.

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Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.

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Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans

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Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

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8 July 2018

Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosamines.

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8 July 2018

Hemoglobin adducts as biomarkers of exposure to and metabolic activation of carcinogenic tobacco-specific nitrosamines.

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8 July 2018

Matabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system

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Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation

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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone induces retinoic acid receptor β hypermethylation through DNA methyltransferase 1 accumulation in esophageal squamous epithelial cells.

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Risk factors for hepatocellular carcinoma in patients with chronic liver disease: a case-control study.

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Synergistic effect of alcohol consumption and body mass on serum concentrations of cytokeratin-18.

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Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys

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Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Influence of hemolysis on routine clinical chemistry testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

The effect of low versus high dose of streptozotocin in cynomolgus monkeys (Macaca fascilularis).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Coexposure to ethanol with N-nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone during lactation of rats: marked increase in O(6)-methylguanine-DNA adducts in maternal mammary gland and in suckling lung and kidney.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Chemically induced DNA damage in isolated rabbit lung cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4327341

27 September 2018

Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of phosphatidylinositol 3-kinase/Akt pathway on the ischemic injury during rat liver graft preservation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of ethanol on insulin receptor substrate-1-mediated signal transduction during rat liver regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activation in rat lung microsomes by chronic ethanol consumption and repeated running exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokeratin inclusions in alcoholic liver disease and their relation to the amount of alcohol intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hemolysis interferences on routine biochemistry parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-alcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipidic last breath of life in patients with alcoholic liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of endoplasmic reticulum stress in emphysema results from cigarette smoke exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of human cells with N-Nitroso(acetoxymethyl)methylamine: distribution patterns of piperidine-sensitive DNA damage at the nucleotide level of resolution are related to the sequence context

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene promoter hypermethylation in mouse lung tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25618784

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/ALCALC/AGU083

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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