(Q35094143)

6 August 2017

title

Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans (English)

1 reference

6 August 2017

Nick P Talbot

1

0 references

Thomas G Smith

object named as

Thomas G Smith

7

0 references

Peter A. Robbins

object named as

Peter A Robbins

6

0 references

Keith L Dorrington

5

object named as

Keith L Dorrington

1 reference

6 August 2017

Quentin P Croft

2

1 reference

6 August 2017

M Kate Curtis

3

1 reference

6 August 2017

Brandon E Turner

4

1 reference

6 August 2017

publication date

11 December 2014

1 reference

6 August 2017

published in

Physiological Reports

1 reference

6 August 2017

volume

2

1 reference

6 August 2017

issue

12

1 reference

HIF and pulmonary vascular responses to hypoxia

6 August 2017

cites work

1 reference

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9 July 2018

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Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension

9 July 2018

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Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation

9 July 2018

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Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

9 July 2018

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Vitamin C supplementation does not improve hypoxia-induced erythropoiesis.

9 July 2018

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Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target.

9 July 2018

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Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation

9 July 2018

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Vitamin C is dispensable for oxygen sensing in vivo

9 July 2018

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Rheumatic manifestations of scurvy: a report of three recent cases in a major urban center and a review

9 July 2018

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The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

9 July 2018

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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

9 July 2018

1 reference

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Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials

9 July 2018

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Prolyl hydroxylases and therapeutics

9 July 2018

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Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1alpha

9 July 2018

1 reference

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Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

9 July 2018

1 reference

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The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

9 July 2018

1 reference

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The human side of hypoxia-inducible factor

9 July 2018

1 reference

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Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate

9 July 2018

1 reference

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9 July 2018

1 reference

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Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

9 July 2018

1 reference

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Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

9 July 2018

1 reference

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Vitamin C pharmacokinetics: implications for oral and intravenous use.

9 July 2018

1 reference

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

9 July 2018

1 reference

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Pulmonary hypertension in chronic obstructive pulmonary disease.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Commercial air travel and in-flight pulmonary hypertension

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Reversible pulmonary hypertension associated with vitamin C deficiency.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Pulmonary artery pressure increases during commercial air travel in healthy passengers.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Separating the direct effect of hypoxia from the indirect effect of changes in cardiac output on the maximum pressure difference across the tricuspid valve in healthy humans

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Two temporal components within the human pulmonary vascular response to approximately 2 h of isocapnic hypoxia.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4332205

Chamber for controlling end-tidal gas tensions over sustained periods in humans

27 September 2018

1 reference

12 December 2020

Systemic pseudovasculitis from scurvy in anorexia nervosa

1 reference

12 December 2020

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

1 reference

12 December 2020

Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia

1 reference

12 December 2020

Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha

1 reference

12 December 2020

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

1 reference

12 December 2020

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

1 reference

12 December 2020

Identifiers

DOI

10.14814/PHY2.12220

1 reference

6 August 2017

1 reference

6 August 2017

1 reference