(Q35112943)

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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

DNA methylation

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Elin Hall

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Karl Bacos

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Clare L Kirkpatrick

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Clare L Kirkpatrick

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Tina Rönn

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Charlotte Ling

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Lena Eliasson

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author name string

Tasnim Dayeh

1

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Europe PubMed Central

PubMed publication ID

6 August 2017

Petr Volkov

2

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Europe PubMed Central

PubMed publication ID

6 August 2017

Sofia Salö

3

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Europe PubMed Central

PubMed publication ID

6 August 2017

Emma Nilsson

5

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Europe PubMed Central

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6 August 2017

Anders H Olsson

6

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Europe PubMed Central

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6 August 2017

Claes B Wollheim

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Europe PubMed Central

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6 August 2017

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6 March 2014

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Europe PubMed Central

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6 August 2017

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Europe PubMed Central

PubMed publication ID

6 August 2017

10

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Europe PubMed Central

PubMed publication ID

6 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

e1004160

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Creative Commons Attribution 4.0 International

6 March 2014

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3945174/fullTextXML

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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

1 reference

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9 July 2018

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

1 reference

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9 July 2018

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

1 reference

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Extracellular calcium influx activates adenylate cyclase 1 and potentiates insulin secretion in MIN6 cells

1 reference

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Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes

1 reference

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Apoptosis in cancer--an update.

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9 July 2018

Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes

1 reference

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Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis.

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Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms.

1 reference

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9 July 2018

Functions of DNA methylation: islands, start sites, gene bodies and beyond

1 reference

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9 July 2018

On the presence and role of human gene-body DNA methylation.

1 reference

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9 July 2018

Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

1 reference

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9 July 2018

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Regulation of calcium in pancreatic α- and β-cells in health and disease

1 reference

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9 July 2018

The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives

1 reference

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9 July 2018

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood

1 reference

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9 July 2018

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

1 reference

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9 July 2018

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

1 reference

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9 July 2018

Gene × environment interactions in type 2 diabetes

1 reference

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9 July 2018

Transcriptomes of the major human pancreatic cell types.

1 reference

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9 July 2018

Dietary methyl-consuming compounds and metabolic syndrome

1 reference

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9 July 2018

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Epigenome-wide association studies for common human diseases

1 reference

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9 July 2018

Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells

1 reference

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9 July 2018

Pancreatic alpha cell mass in European subjects with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

DNA methylation and demethylation in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Plasma membrane repair and cellular damage control: the annexin survival kit.

1 reference

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9 July 2018

Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a

1 reference

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9 July 2018

Genomics, type 2 diabetes, and obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Conserved role of intragenic DNA methylation in regulating alternative promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Genetics of type 1 diabetes: what's next?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

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Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

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Cyclic AMP signaling in pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3945174

9 July 2018

Epigenetics: a molecular link between environmental factors and type 2 diabetes

1 reference

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Human DNA methylomes at base resolution show widespread epigenomic differences

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Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

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9 July 2018

Isolating human islets of Langerhans causes loss of decay accelerating factor (CD55) on beta-cells

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Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function

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9 July 2018

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.

1 reference

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9 July 2018

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

1 reference

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Gene expression profile in obesity and type 2 diabetes mellitus

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Perceptions of epigenetics

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1 reference

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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

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Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model

1 reference

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Bioconductor: open software development for computational biology and bioinformatics

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Statistical significance for genomewide studies

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9 July 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

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9 July 2018

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

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9 July 2018

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Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study

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9 July 2018

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1 reference

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9 July 2018

Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase

1 reference

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9 July 2018

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

1 reference

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9 July 2018

Genetic and nutritional factors in the etiology and pathogenesis of diabetes mellitus

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9 July 2018

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

1 reference

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27 September 2018

High density DNA methylation array with single CpG site resolution

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27 September 2018

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

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27 September 2018

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27 September 2018

Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies

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27 September 2018

Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol.

1 reference

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27 September 2018

Proliferation of sorted human and rat beta cells

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27 September 2018

Islet Neogenesis Associated Protein (INGAP) modulates gene expression in cultured neonatal rat islets.

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27 September 2018

BMP4 regulates pancreatic progenitor cell expansion through Id2.

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27 September 2018

Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function

1 reference

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27 September 2018

Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells.

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27 September 2018

Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

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27 September 2018

Exenatide blocks JAK1-STAT1 in pancreatic beta cells

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/24603685

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PGEN.1004160

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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0 references

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