(Q35130480)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16990249%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16990249%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

2

1 reference

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30 December 2019

Carmen Losasso

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16990249%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Alessandro Desideri

5

1 reference

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30 December 2019

author name string

Paola Fiorani

1

1 reference

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30 December 2019

Silvia Castelli

4

1 reference

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30 December 2019

language of work or name

English

0 references

publication date

20 September 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16990249%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

published in

Nucleic Acids Research

1 reference

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30 December 2019

volume

34

1 reference

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30 December 2019

issue

18

1 reference

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30 December 2019

page(s)

5093-5100

1 reference

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describes a project that uses

30 December 2019

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1636438/fullTextXML

inferred from PubMed Central ID database lookup

cites work

An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Novel mutation of topoisomerase I in rendering cells resistant to camptothecin.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Structure and hydration of the DNA-human topoisomerase I covalent complex.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

A model for the mechanism of human topoisomerase I

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

The domain organization of human topoisomerase I

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

DNA topoisomerases: essential enzymes and lethal targets

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Topoisomerase I has a strong binding preference for a conserved hexadecameric sequence in the promoter region of the rRNA gene from Tetrahymena pyriformis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Mechanisms of camptothecin resistance by human topoisomerase I mutations

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Topoisomerase I inhibitors: selectivity and cellular resistance.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636438

Reconstitution of enzymatic activity by the association of the cap and catalytic domains of human topoisomerase I

27 September 2018

1 reference

12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

12 December 2020

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin

1 reference

12 December 2020

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

1 reference

12 December 2020

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

1 reference

12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

12 December 2020

Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKL670

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16990249%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16990249%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

16990249

1 reference