(Q38351710)

2 September 2017

Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I. (English)

1 reference

2 September 2017

Alessandro Bruselles

2

0 references

Mattia Falconi

Mattia Falconi

3

0 references

Giovanni Chillemi

Giovanni Chillemi

4

0 references

Alessandro Desideri

Alessandro Desideri

Paola Alejandra Fiorani Celedon

5

0 references

1

Paola Fiorani

1 reference

2 September 2017

Piero Benedetti

6

1 reference

PubMed ID

12904303

2 September 2017

language of work or name

English

0 references

publication date

6 August 2003

1 reference

Journal of Biological Chemistry

2 September 2017

1 reference

2 September 2017

278

1 reference

2 September 2017

44

1 reference

2 September 2017

43268-43275

1 reference

DNA topoisomerases: essential enzymes and lethal targets

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

A model for the mechanism of human topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

21 January 2018

1 reference

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Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

21 January 2018

1 reference

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Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

21 January 2018

1 reference

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A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I.

21 January 2018

1 reference

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Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions

21 January 2018

1 reference

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Reconstitution of human topoisomerase I by fragment complementation

21 January 2018

1 reference

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A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Structure and hydration of the DNA-human topoisomerase I covalent complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Protein concerted motions in the DNA-human topoisomerase I complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

The role of histidine 632 in catalysis by human topoisomerase I.

21 January 2018

1 reference

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Investigating the biological functions of DNA topoisomerases in eukaryotic cells

21 January 2018

1 reference

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Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

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Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

21 January 2018

1 reference

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Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

Expression of human topoisomerase I with a partial deletion of the linker region yields monomeric and dimeric enzymes that respond differently to camptothecin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303899200

21 January 2018

Identifiers

DOI

10.1074/JBC.M303899200

1 reference

2 September 2017

1 reference

PubMed ID

12904303