(Q35132636)

6 August 2017

1 reference

title

The DNA damage checkpoint and human cancer (English)

1 reference

6 August 2017

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Schultz LB

1

1 reference

6 August 2017

Chehab NH

2

1 reference

6 August 2017

Malikzay A

3

1 reference

6 August 2017

DiTullio RA Jr

4

1 reference

6 August 2017

Stavridi ES

5

1 reference

6 August 2017

Halazonetis TD

6

1 reference

6 August 2017

1 January 2000

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Cold Spring Harbor Symposia on Quantitative Biology

6 August 2017

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6 August 2017

65

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6 August 2017

489-498

1 reference

A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

6 August 2017

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Caffeine inhibits the checkpoint kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Replication checkpoint enforced by kinases Cds1 and Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Mammalian DNA mismatch repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

DNA structure checkpoint pathways in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Cell cycle checkpoints: preventing an identity crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

DNA recombination: the replication connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

DNA damage checkpoint in budding yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

In situ visualization of DNA double-strand break repair in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

21 January 2018

When checkpoints fail

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2000.65.489

21 January 2018

Identifiers

DOI

10.1101/SQB.2000.65.489

1 reference

6 August 2017

1 reference