(Q35134641)

6 August 2017

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title

p66(Shc): at the crossroad of oxidative stress and the genetics of aging (English)

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6 August 2017

Sally Purdom

1

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6 August 2017

Qin M Chen

series ordinal

2

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6 August 2017

publication date

1 May 2003

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Trends in Molecular Medicine

6 August 2017

published in

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6 August 2017

volume

9

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6 August 2017

issue

5

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6 August 2017

page(s)

206-210

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The free radical theory of aging matures

6 August 2017

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Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

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Mutations in PROP1 cause familial combined pituitary hormone deficiency

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Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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7 January 2021

Oxidative stress, caloric restriction, and aging

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7 January 2021

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

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Evolution of Shc functions from nematode to human

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Shc signaling in differentiating neural progenitor cells.

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Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain.

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The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

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7 January 2021

Not all Shc's roads lead to Ras

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The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway

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7 January 2021

Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes

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7 January 2021

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

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7 January 2021

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7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

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7 January 2021

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

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7 January 2021

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

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7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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7 January 2021

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

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7 January 2021

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7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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7 January 2021

Genetic pathways that regulate ageing in model organisms

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7 January 2021

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7 January 2021

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7 January 2021

DNA methylation and atherosclerosis

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7 January 2021

Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer

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7 January 2021

Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver

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7 January 2021

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

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7 January 2021

Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament

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7 January 2021

Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals

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7 January 2021

Extended longevity in mice lacking the insulin receptor in adipose tissue

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7 January 2021

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Identifiers

DOI

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6 August 2017

1 reference