(Q35140143)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25250572%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3 (English)

1 reference

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19 February 2020

6

1 reference

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19 February 2020

Markus Bleich

14

1 reference

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19 February 2020

Gerardo Gamba

18

1 reference

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19 February 2020

David H. Ellison

20

1 reference

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19 February 2020

author name string

James A McCormick

1

1 reference

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19 February 2020

Chao-Ling Yang

2

1 reference

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19 February 2020

Chong Zhang

3

1 reference

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19 February 2020

Brittney Davidge

4

1 reference

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19 February 2020

Katharina I Blankenstein

5

1 reference

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19 February 2020

Bethzaida Yarbrough

7

1 reference

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19 February 2020

Nicholas P Meermeier

8

1 reference

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19 February 2020

Hae J Park

9

1 reference

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19 February 2020

Belinda McCully

10

1 reference

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19 February 2020

Mark West

11

1 reference

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19 February 2020

Aljona Borschewski

12

1 reference

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19 February 2020

Nina Himmerkus

13

1 reference

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19 February 2020

Sebastian Bachmann

15

1 reference

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19 February 2020

Kerim Mutig

16

1 reference

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19 February 2020

Eduardo R Argaiz

17

1 reference

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19 February 2020

Jeffrey D Singer

19

1 reference

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19 February 2020

language of work or name

English

0 references

publication date

24 September 2014

1 reference

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Journal of Clinical Investigation

19 February 2020

published in

1 reference

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19 February 2020

volume

124

1 reference

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19 February 2020

issue

11

1 reference

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19 February 2020

page(s)

4723-4736

1 reference

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describes a project that uses

19 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4347254/fullTextXML

inferred from PubMed Central ID database lookup

cites work

A molecular update on pseudohypoaldosteronism type II

1 reference

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28 July 2018

1 reference

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Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

SPAK differentially mediates vasopressin effects on sodium cotransporters.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

28 July 2018

1 reference

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Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

28 July 2018

1 reference

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A SPAK isoform switch modulates renal salt transport and blood pressure

28 July 2018

1 reference

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The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

28 July 2018

1 reference

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The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes

28 July 2018

1 reference

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An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

28 July 2018

1 reference

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WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter

28 July 2018

1 reference

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Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

28 July 2018

1 reference

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

28 July 2018

1 reference

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Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease

28 July 2018

1 reference

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Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

28 July 2018

1 reference

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

28 July 2018

1 reference

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

28 July 2018

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11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.

28 July 2018

1 reference

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Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter

28 July 2018

1 reference

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WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

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27 September 2018

1 reference

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Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

27 September 2018

1 reference

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Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

27 September 2018

1 reference

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Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

27 September 2018

1 reference

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SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

27 September 2018

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27 September 2018

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Constitutive turnover of cyclin E by Cul3 maintains quiescence

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4347254

WNK1 and WNK4 modulate CFTR activity.

27 September 2018

1 reference

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Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats

27 September 2018

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Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

27 September 2018

1 reference

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Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

27 September 2018

1 reference

12 December 2020

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model

1 reference

12 December 2020

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma

1 reference

12 December 2020

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1 reference

12 December 2020

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI76126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25250572%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25250572%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

25250572

1 reference