(Q53051338)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821705%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice (English)

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18 March 2020

8

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18 March 2020

author name string

Koichiro Susa

1

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18 March 2020

Eisei Sohara

2

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18 March 2020

Tatemitsu Rai

3

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18 March 2020

Moko Zeniya

4

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18 March 2020

Yutaro Mori

5

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18 March 2020

Takayasu Mori

6

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18 March 2020

Motoko Chiga

7

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18 March 2020

Hidenori Nishida

9

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18 March 2020

Daiei Takahashi

10

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18 March 2020

Kiyoshi Isobe

11

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18 March 2020

Yuichi Inoue

12

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18 March 2020

Kenta Takeishi

13

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18 March 2020

Naoki Takeda

14

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18 March 2020

Sei Sasaki

15

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18 March 2020

Shinichi Uchida

16

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18 March 2020

publication date

12 May 2014

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18 March 2020

published in

Human Molecular Genetics

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18 March 2020

volume

23

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18 March 2020

page(s)

5052-5060

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18 March 2020

issue

19

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Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate

18 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Phenotypic and genetic heterogeneity of familial hyperkalaemic hypertension (Gordon syndrome).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Human hypertension caused by mutations in WNK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Role of the WNK-activated SPAK kinase in regulating blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

KLHL2 interacts with and ubiquitinates WNK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of Renin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

A highly efficient recombineering-based method for generating conditional knockout mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Simple and highly efficient BAC recombineering using galK selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU217

21 January 2018

Identifiers

DOI

10.1093/HMG/DDU217

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821705%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference