(Q35166988)

6 August 2017

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title

The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases (English)

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6 August 2017

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Christoph Hölscher

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6 August 2017

language of work or name

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27 June 2003

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Medical Microbiology and Immunology

6 August 2017

published in

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6 August 2017

volume

193

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6 August 2017

issue

1

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6 August 2017

page(s)

1-17

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Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells

6 August 2017

cites work

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12 December 2020

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

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12 December 2020

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

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12 December 2020

Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells

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12 December 2020

Innate immunity: impact on the adaptive immune response

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12 December 2020

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

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12 December 2020

IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis

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12 December 2020

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

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12 December 2020

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

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12 December 2020

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

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12 December 2020

Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3

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12 December 2020

Direct interaction of STAT4 with the IL-12 receptor

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12 December 2020

Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection

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12 December 2020

Molecular cloning and characterization of murine IL-12 genes.

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12 December 2020

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

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12 December 2020

Mice lacking IL-12 develop polarized Th1 cells during viral infection

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12 December 2020

Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts

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12 December 2020

Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.

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12 December 2020

Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock

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12 December 2020

Biosynthesis and posttranslational regulation of human IL-12.

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12 December 2020

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

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12 December 2020

Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells

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12 December 2020

Cytokines induce the development of functionally heterogeneous T helper cell subsets

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12 December 2020

Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency

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12 December 2020

The instructive role of innate immunity in the acquired immune response

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12 December 2020

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

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12 December 2020

Lineage commitment in the immune system: the T helper lymphocyte grows up.

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12 December 2020

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

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12 December 2020

C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages.

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12 December 2020

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

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12 December 2020

The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis

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12 December 2020

Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10.

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12 December 2020

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

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12 December 2020

Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

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12 December 2020

Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells

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12 December 2020

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

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12 December 2020

c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

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12 December 2020

Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology

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12 December 2020

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

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12 December 2020

Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes

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12 December 2020

Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo

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12 December 2020

IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18.

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12 December 2020

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor

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12 December 2020

Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

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12 December 2020

Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice.

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12 December 2020

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

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12 December 2020

Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection

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12 December 2020

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

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12 December 2020

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

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12 December 2020

Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.

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12 December 2020

Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses

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12 December 2020

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

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12 December 2020

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

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12 December 2020

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

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12 December 2020

IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites

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12 December 2020

Immune responses to intracellular bacteria.

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12 December 2020

The Stat family in cytokine signaling

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12 December 2020

The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

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12 December 2020

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

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12 December 2020

Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells

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12 December 2020

Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling

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12 December 2020

Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction

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12 December 2020

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

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12 December 2020

Alloantigen-reactive Th1 development in IL-12-deficient mice

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12 December 2020

Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells

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12 December 2020

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

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12 December 2020

IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.

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12 December 2020

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans

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12 December 2020

IL-12 is not required for induction of type 1 cytokine responses in viral infections

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12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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12 December 2020

Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response

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12 December 2020

Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii

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12 December 2020

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

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12 December 2020

Regulation of interleukin-12 production by G-protein-coupled receptors

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12 December 2020

A unique role for IL-23 in promoting cellular immunity

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12 December 2020

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12

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12 December 2020

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

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12 December 2020

The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

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12 December 2020

IFN-gamma production by antigen-presenting cells: mechanisms emerge.

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12 December 2020

In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting

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12 December 2020

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

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12 December 2020

In vivo production and function of IL-12 p40 homodimers.

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12 December 2020

Cloning and characterization of a mouse IL-12 receptor-beta component

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12 December 2020

The role of interleukin-13 in infectious diseases and allergy

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12 December 2020

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages

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12 December 2020

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

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12 December 2020

Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins

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12 December 2020

Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2).

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12 December 2020

Regulation of interleukin-12 production in antigen-presenting cells

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12 December 2020

Requirement for type 2 NO synthase for IL-12 signaling in innate immunity

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12 December 2020

Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells

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12 December 2020

Defective NK cell activity and Th1 response in IL-18-deficient mice

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12 December 2020

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit

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12 December 2020

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

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12 December 2020

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

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12 December 2020

Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells.

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12 December 2020

Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4.

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12 December 2020

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

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12 December 2020

Cloning and expression of murine IL-12

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12 December 2020

IL-12-deficient mice are defective but not devoid of type 1 cytokine responses.

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12 December 2020

IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology

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12 December 2020

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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12 December 2020

IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes

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12 December 2020

IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic Cells

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12 December 2020

Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers.

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12 December 2020

Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ

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12 December 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

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12 December 2020

Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells.

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12 December 2020

Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptide

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12 December 2020

Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation

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12 December 2020

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12 December 2020

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

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12 December 2020

Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling

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12 December 2020

The role of Stat4 in species-specific regulation of Th cell development by type I IFNs.

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12 December 2020

Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency

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12 December 2020

Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection

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12 December 2020

Selective suppression of IL-12 production by chemoattractants

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12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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12 December 2020

In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas

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12 December 2020

IL-12 expression in AIDS-related lymphoma B cell lines.

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12 December 2020

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

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12 December 2020

Cloning and characterization of a novel class I cytokine receptor

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12 December 2020

Functional diversity of helper T lymphocytes

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12 December 2020

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

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12 December 2020

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

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12 December 2020

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

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12 December 2020

Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription

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12 December 2020

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

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12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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12 December 2020

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells

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12 December 2020

In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.

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12 December 2020

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

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12 December 2020

Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice

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12 December 2020

Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase

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12 December 2020

Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit

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12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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12 December 2020

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

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12 December 2020

Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells

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12 December 2020

IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice

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12 December 2020

JNK2 and IKKbeta are required for activating the innate response to viral infection

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12 December 2020

STATs and gene regulation

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12 December 2020

CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal

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12 December 2020

Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis

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12 December 2020

Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

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12 December 2020

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

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12 December 2020

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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12 December 2020

IL-12 receptor. II. Distribution and regulation of receptor expression

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12 December 2020

Cloning of a new cytokine that induces IFN-gamma production by T cells

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12 December 2020

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA

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12 December 2020

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

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12 December 2020

Signaling and transcription in T helper development

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12 December 2020

The interleukin-12 beta subunit (p40) maps to mouse chromosome 11

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12 December 2020

A protective and agonistic function of IL-12p40 in mycobacterial infection.

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12 December 2020

Molecular characterization of interleukin 12

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12 December 2020

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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12 December 2020

Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1)

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12 December 2020

10.1007/S00430-003-0186-X

Identifiers

DOI

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6 August 2017

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