(Q35167628)

6 August 2017

1 reference

title

Cholesterol: from heart attacks to Alzheimer's disease (English)

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6 August 2017

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1

Robert L Raffai

1 reference

6 August 2017

Karl H Weisgraber

2

1 reference

6 August 2017

1 July 2003

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Journal of Lipid Research

6 August 2017

1 reference

6 August 2017

44

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6 August 2017

8

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6 August 2017

1423-1430

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 August 2017

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Alzheimer disease therapy: can the amyloid cascade be halted?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Clearing the brain's amyloid cobwebs

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Statins and the risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

A detergent-insoluble membrane compartment contains A beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Cholesterol-dependent aggregation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Cholesterol metabolism in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Synthesis and processing of apolipoprotein E in human brain cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

CNS synaptogenesis promoted by glia-derived cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

ApoE, Alzheimer's disease, and recovery from brain stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Association of apolipoprotein E polymorphism with outcome after head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Reversal of presynaptic deficits of apolipoprotein E-deficient mice in human apolipoprotein E transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R300007-JLR200

10.1194/JLR.R300007-JLR200

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12837845