(Q35182054)

7 August 2017

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title

Neuroprotective strategies in Parkinson's disease : an update on progress (English)

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7 August 2017

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Edna Grünblatt

2

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Moussa B. H. Youdim

series ordinal

6

object named as

Moussa B H Youdim

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7 August 2017

1

Silvia Mandel

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7 August 2017

3

Peter Riederer

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7 August 2017

Manfred Gerlach

4

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PubMed ID

12873156

7 August 2017

Yona Levites

series ordinal

5

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7 August 2017

1 January 2003

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7 August 2017

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7 August 2017

17

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7 August 2017

729-762

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7 August 2017

10

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https://scigraph.springernature.com/pub.10.2165/00023210-200317100-00004

7 August 2017

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1 reference

12 December 2020

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

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12 December 2020

Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles

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12 December 2020

Neuronal protective and rescue effects of deprenyl against MPP+ dopaminergic toxicity

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12 December 2020

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

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12 December 2020

Nicotinic Stimulation of [3H]Acetylcholine Release from Mouse Cerebral Cortical Synaptosomes

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12 December 2020

The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.

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12 December 2020

Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission

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12 December 2020

Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB

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12 December 2020

Presynaptic modulation of transmitter release by nicotinic receptors.

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12 December 2020

Involvement of iron in MPP+ toxicity in substantia nigra: protection by desferrioxamine.

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12 December 2020

Suppression of hydroxyl radical formation and protection of nigral neurons by l-deprenyl (selegiline)

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12 December 2020

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain

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12 December 2020

Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

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12 December 2020

Intravenous amantadine improves levadopa-induced dyskinesias: an acute double-blind placebo-controlled study.

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12 December 2020

The effect of amantadine on levodopa-induced dyskinesias in Parkinson's disease: a double-blind, placebo-controlled study

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12 December 2020

ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE).

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12 December 2020

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study.

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12 December 2020

Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice

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12 December 2020

A review of latest research findings on the health promotion properties of tea.

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12 December 2020

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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12 December 2020

Addiction to nicotine is due to high intrinsic levels of dopamine

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12 December 2020

Nicotinic receptors and Parkinson's disease

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12 December 2020

Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine

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12 December 2020

Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity.

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12 December 2020

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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12 December 2020

Reefer madness--the federal response to California's medical-marijuana law.

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12 December 2020

Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys.

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12 December 2020

Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice

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12 December 2020

Genomics, gene expression and DNA arrays

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12 December 2020

Selective acetylenic 'suicide' and reversible inhibitors of monoamine oxidase types A and B

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12 December 2020

A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study

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12 December 2020

Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the off and on conditions with [(18)F]FDG-PET.

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12 December 2020

Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells.

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12 December 2020

Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Parkinson Study Group

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12 December 2020

Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.

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12 December 2020

Comparative Review of Dopamine Receptor Agonists in Parkinson's Disease

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12 December 2020

Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease

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12 December 2020

Neuroprotection in Parkinson's disease: love story or mission impossible?

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12 December 2020

NMDA antagonists: their role in neuroprotection

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12 December 2020

Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

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12 December 2020

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

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12 December 2020

Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.

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12 December 2020

Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamen.

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12 December 2020

Prostaglandins stimulate calcium-dependent glutamate release in astrocytes.

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12 December 2020

Deprenyl (selegiline) combined with levodopa and a decarboxylase inhibitor in the treatment of Parkinson's disease

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12 December 2020

Pharmacology of cannabinoid CB1 and CB2 receptors.

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12 December 2020

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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12 December 2020

The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons

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12 December 2020

On the mode of action of L-deprenyl in the human central nervous system

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12 December 2020

Neuroprotective effect of the iron chelator desferrioxamine against MPP+ toxicity on striatal dopaminergic terminals

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12 December 2020

Amantadine for dyskinesia in patients affected by severe Parkinson's disease.

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12 December 2020

Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue.

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12 December 2020

Amantadine in the Treatment of Parkinson's Disease

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12 December 2020

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

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12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

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12 December 2020

Amantadine in Parkinson's disease. Review of more than two years' experience

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12 December 2020

Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation

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12 December 2020

Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation

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12 December 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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12 December 2020

The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

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12 December 2020

Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.

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12 December 2020

Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

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12 December 2020

Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease

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12 December 2020

Neuroprotection by the metabolic antioxidant alpha-lipoic acid

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12 December 2020

Rasagiline Mesylate, a New Mao-B Inhibitor for the Treatment of Parkinson's Disease: A Double-Blind Study as Adjunctive Therapy to Levodopa

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12 December 2020

Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes

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12 December 2020

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain.

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12 December 2020

Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants

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12 December 2020

Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea.

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12 December 2020

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

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12 December 2020

Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice.

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12 December 2020

6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation

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12 December 2020

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12 December 2020

The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.

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12 December 2020

Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors

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12 December 2020

Free radical scavenging properties of apomorphine enantiomers and dopamine: possible implication in their mechanism of action in parkinsonism

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12 December 2020

Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain

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12 December 2020

Basal forebrain neurons in the dementia of Parkinson disease

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12 December 2020

The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid.

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12 December 2020

Glutamate receptor antagonism: neurotoxicity, anti-akinetic effects, and psychosis.

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12 December 2020

Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants

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12 December 2020

Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss

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12 December 2020

Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression

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12 December 2020

[Subcutaneous apomorphine in the treatment of Parkinson's disease]

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12 December 2020

Pharmacology of rasagiline (N-propargyl-1R-aminoindan).

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12 December 2020

Amantadine for Parkinson's disease

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12 December 2020

A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease

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12 December 2020

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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12 December 2020

Protective effects of tea polyphenols against oxidative damage to red blood cells

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12 December 2020

Neuroprotective effect of memantine demonstrated in vivo and in vitro.

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12 December 2020

Vitamin E: interactions with free radicals and ascorbate

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12 December 2020

Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.

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12 December 2020

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

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12 December 2020

(-)-Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase

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12 December 2020

Effects of nicotine chewing gum on UPDRS score and P300 in early-onset parkinsonism

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12 December 2020

Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism

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12 December 2020

Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

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12 December 2020

Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma

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12 December 2020

Increased life expectancy resulting from addition of L-deprenyl to Madopar treatment in Parkinson's disease: a longterm study

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12 December 2020

Autosomal dominant Parkinson's disease and alpha-synuclein.

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12 December 2020

Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine

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12 December 2020

Bromocriptine scavenges methamphetamine-induced hydroxyl radicals and attenuates dopamine depletion in mouse striatum

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12 December 2020

Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury

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12 December 2020

Determination and characterization of a cannabinoid receptor in rat brain

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12 December 2020

Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action

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12 December 2020

Increased efflux rather than oxidation is the mechanism of glutathione depletion by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

Apoptosis in neurodegenerative diseases: facts and controversies

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12 December 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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12 December 2020

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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12 December 2020

Temporal profiling of methamphetamine-induced changes in gene expression in the mouse brain: evidence from cDNA array

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12 December 2020

Intranigral iron injection induces behavioral and biochemical "parkinsonism" in rats

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12 December 2020

Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist.

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12 December 2020

Pharmacological changes in dopaminergic systems induced by long-term administration of amantadine

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12 December 2020

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

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12 December 2020

The effect of deprenyl and levodopa on the progression of Parkinson's disease

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12 December 2020

Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction.

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12 December 2020

Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

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12 December 2020

Deprenyl as symptomatic therapy in Parkinson's disease

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12 December 2020

Microdialysis studies on 3,4-methylenedioxyamphetamine and structurally related analogues

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12 December 2020

Antioxidant property of pramipexole independent of dopamine receptor activation in neuroprotection

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12 December 2020

Excitotoxic cell death

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12 December 2020

Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum

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12 December 2020

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12 December 2020

Effect of low-dose treatment with selegiline on dopamine transporter (DAT) expression and amphetamine-induced dopamine release in vivo

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12 December 2020

Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils

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12 December 2020

Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity.

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12 December 2020

Increased cerebral iron uptake in Wilson's disease: a 52Fe-citrate PET study

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12 December 2020

Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse.

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12 December 2020

Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

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12 December 2020

The nicotinic receptor genes

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12 December 2020

Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures

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12 December 2020

Effect of (-)deprenyl in long-term treatment of Parkinson's disease. A 10-years experience

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12 December 2020

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

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12 December 2020

Chronic nicotine treatment counteracts the disappearance of tyrosine-hydroxylase-immunoreactive nerve cell bodies, dendrites and terminals in the mesostriatal dopamine system of the male rat after partial hemitransection

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12 December 2020

A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease

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12 December 2020

Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway

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12 December 2020

Chronic nicotine treatment partly protects against the 1-methyl-4-phenyl-2,3,6-tetrahydropyridine-induced degeneration of nigrostriatal dopamine neurons in the black mouse.

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12 December 2020

Clinical trial of a new type promptly acting psychoenergetic agent (phenyl-isopropyl-methylpropinyl-HCl, "E-250")

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12 December 2020

Monoamine oxidase B, smoking, and Parkinson's disease

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12 December 2020

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

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12 December 2020

Brain and brain monoamine oxidase in aging and in dementia of Alzheimer's type

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12 December 2020

Amantadine and a fixed combination of levodopa and carbidopa in the treatment of Parkinson's disease

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12 December 2020

Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity

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12 December 2020

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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12 December 2020

Success and problems of long-term levodopa therapy in Parkinson's disease

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12 December 2020

Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia

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12 December 2020

Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?

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12 December 2020

Smoker's melanosis may explain the lower hearing loss and lower frequency of Parkinson's disease found among tobacco smokers--a new hypothesis

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12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

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12 December 2020

Selegiline as neuroprotective therapy in Parkinson's disease: concepts and controversies.

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12 December 2020

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12 December 2020

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

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12 December 2020

Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice

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12 December 2020

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

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12 December 2020

Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.

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12 December 2020

Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO B.

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12 December 2020

Apoptosis in neurodegenerative diseases: the role of mitochondria

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12 December 2020

Muscarinic and nicotinic modulation of cortical acetylcholine release monitored by in vivo microdialysis in freely moving adult rats.

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12 December 2020

COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages?

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12 December 2020

Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000

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12 December 2020

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

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12 December 2020

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

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12 December 2020

The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

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12 December 2020

Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis.

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12 December 2020

Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake

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12 December 2020

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

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12 December 2020

Neuroprotective effect of riluzole in a primate model of Parkinson's disease: behavioral and histological evidence

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12 December 2020

MPTP-Parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways.

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12 December 2020

Beneficial effects of amantadine on L-dopa-induced dyskinesias in Parkinson's disease

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12 December 2020

Some observations upon a new inhibitor of monoamine oxidase in brain tissue.

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12 December 2020

Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

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12 December 2020

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

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12 December 2020

Cerebrospinal fluid homovanillic acid in the DATATOP study on Parkinson's disease. Parkinson Study Group

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12 December 2020

Prospects for the treatment of Parkinson's disease using neural grafts

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12 December 2020

The pharmacological basis of the beneficial effects of (-)deprenyl (selegiline) in Parkinson's and Alzheimer's diseases.

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12 December 2020

The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase

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12 December 2020

Interleukin-1 beta increases prostaglandin E2 in rat astrocyte cultures: modulatory effect of neuropeptides

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12 December 2020

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

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12 December 2020

Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture

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12 December 2020

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

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12 December 2020

Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

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12 December 2020

Why (--)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects

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12 December 2020

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

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12 December 2020

Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.

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12 December 2020

Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer.

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12 December 2020

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

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12 December 2020

Gene expression profile of aging and its retardation by caloric restriction

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12 December 2020

Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

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12 December 2020

Antiparkinsonian drugs and in vitro excitotoxicity

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12 December 2020

The possible role of iron in the etiopathology of Parkinson's disease

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12 December 2020

Neuroprotective effects of the dopamine D2/D3 agonist pramipexole against postischemic or methamphetamine-induced degeneration of nigrostriatal neurons.

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12 December 2020

Comparative pharmacological analysis of the optical isomers of phenyl-isopropyl-methyl-propinylamine (E-250)

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12 December 2020

Structural aspects of antioxidant activity of flavonoids

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12 December 2020

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

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12 December 2020

Retracted article on dopaminergic neurotoxicity of MDMA

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12 December 2020

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

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12 December 2020

Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro

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12 December 2020

Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells

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12 December 2020

Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)deprenyl

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12 December 2020

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

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12 December 2020

Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration

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12 December 2020

(-)-Deprenyl alters the survival of adult murine facial motoneurons after axotomy: increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants

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12 December 2020

Iron-reducing and free-radical-scavenging properties of apomorphine and some related benzylisoquinolines

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12 December 2020

Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease

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12 December 2020

Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse

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12 December 2020

Free radical scavengers: chemical concepts and clinical relevance.

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12 December 2020

High doses of vitamin E in the treatment of disorders of the central nervous system in the aged

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12 December 2020

More recent lessons from amantadine

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12 December 2020

Effect of 6-hydroxydopa on catecholamine-containing neurons in brains of newborn rats.

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12 December 2020

Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice.

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12 December 2020

Modulation of neurotransmission by cannabinoids in the basal ganglia

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12 December 2020

Apoptosis in neurodegenerative disorders

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12 December 2020

Deprenyl suppresses the oxidant stress associated with increased dopamine turnover

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12 December 2020

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

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12 December 2020

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

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12 December 2020

New dawn of cannabinoid pharmacology

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12 December 2020

Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes

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12 December 2020

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

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12 December 2020

The role of MAO in MPTP toxicity--a review

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12 December 2020

Markers of apoptosis: methods for elucidating the mechanism of apoptotic cell death from the nervous system

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12 December 2020

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

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12 December 2020

The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurones in culture.

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12 December 2020

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

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12 December 2020

Marijuana for parkinsonian tremor

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12 December 2020

Absence of mutations in superoxide dismutase and catalase genes in patients with Parkinson's disease

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12 December 2020

Ameliorative effects of tea catechins on active oxygen-related nerve cell injuries

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12 December 2020

Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures

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12 December 2020

Bromocriptine protects dopaminergic neurons from levodopa-induced toxicity by stimulating D(2)receptors

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12 December 2020

cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson's disease

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12 December 2020

Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes

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12 December 2020

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

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12 December 2020

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

1 reference

12 December 2020

Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine

1 reference

12 December 2020

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

1 reference

12 December 2020

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

1 reference

12 December 2020

Reductions in acetylcholine and nicotine binding in several degenerative diseases

1 reference

12 December 2020

Alpha-synuclein in Lewy bodies

1 reference

12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

12 December 2020

Behaviour of (-)-deprenyl and its analogues.

1 reference

12 December 2020

Genetics of Parkinson's disease

1 reference

12 December 2020

Pergolide in the treatment of Parkinson's disease.

1 reference

12 December 2020

Use of a cDNA microarray to analyse gene expression patterns in human cancer

1 reference

12 December 2020

Cigarette smoking and protection from Parkinson's disease: false association or etiologic clue?

1 reference

12 December 2020

Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

1 reference

12 December 2020

Deprenyl as prophylaxis against Parkinson's disease?

1 reference

12 December 2020

Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease.

1 reference

12 December 2020

Dopamine agonists and neuroprotection in Parkinson's disease

1 reference

12 December 2020

Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical

1 reference

12 December 2020

Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray

1 reference

12 December 2020

The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain

1 reference

12 December 2020

Microarray analysis of hippocampal gene expression in global cerebral ischemia

1 reference

12 December 2020

Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease

1 reference

12 December 2020

Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.

1 reference

12 December 2020

Oxidative stress: free radical production in neural degeneration.

1 reference

12 December 2020

Use, abuse and dependence of ecstasy and related drugs in adolescents and young adults-a transient phenomenon? Results from a longitudinal community study

1 reference

12 December 2020

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

12 December 2020

Treatment of Parkinson's disease with amantadine and levodopa. A one-year study

1 reference

12 December 2020

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

1 reference

12 December 2020

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1 reference

12 December 2020

Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease

1 reference

12 December 2020

Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.

1 reference

12 December 2020

Is brain superoxide dismutase activity increased following chronic treatment with 1-deprenyl?

1 reference

12 December 2020

Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra.

1 reference

12 December 2020

Time sequences of dopaminergic cell death in Parkinson's disease: indications for neuroprotective studies.

1 reference

12 December 2020

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.

1 reference

12 December 2020

(-)deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male mice.

1 reference

12 December 2020

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

1 reference

12 December 2020

Chronic nicotine treatment counteracts the decrease in extracellular neostriatal dopamine induced by a unilateral transection at the mesodiencephalic junction in rats: a microdialysis study

1 reference

12 December 2020

Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein.

1 reference

12 December 2020

Induction of cytochrome P-450 enzymes via tobacco smoke: a potential mechanism for developing resistance to environmental toxins as related to parkinsonism and other neurologic diseases.

1 reference

12 December 2020

Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson's disease

1 reference

12 December 2020

Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence

1 reference

12 December 2020

alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.

1 reference

12 December 2020

A synergistic neurotrophic response to l-dihydroxyphenylalanine and nerve growth factor

1 reference

12 December 2020

The effect of age on the activity and molecular properties of human brain monoamine oxidase

1 reference

12 December 2020

Transplantation of embryonic dopamine neurons for severe Parkinson's disease

1 reference

12 December 2020

In-vivo and in-vitro assessment of the free-radical-scavenger activity of Ginkgo flavone glycosides at high concentration

1 reference

12 December 2020

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1 reference

12 December 2020

Bioenergetic approaches for neuroprotection in Parkinson's disease

1 reference

12 December 2020

Apomorphine protects against MPTP-induced neurotoxicity in mice.

1 reference

12 December 2020

Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity

1 reference

12 December 2020

The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons

1 reference

12 December 2020

Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice

1 reference

12 December 2020

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

1 reference

12 December 2020

Understanding Parkinson's disease.

1 reference

12 December 2020

Selegiline can mediate neuronal rescue rather than neuronal protection

1 reference

12 December 2020

Theaflavin-3,3'-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-kappaB in macrophages

1 reference

12 December 2020

Use of Amantadine in Parkinson's Disease. Results of a Double-blind Trial

1 reference

12 December 2020

Anticholinergic and membrane activities of amantadine in neuromuscular transmission

1 reference

12 December 2020

Sustained bromocriptine therapy in previously untreated patients with Parkinson's disease

1 reference

12 December 2020

Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl

1 reference

12 December 2020

Scavenging effects of dopamine agonists on nitric oxide radicals.

1 reference

12 December 2020

Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.

1 reference

12 December 2020

Drug therapy for Parkinson's disease in the elderly

1 reference

12 December 2020

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1 reference

12 December 2020

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

12 December 2020

Turning of nerve growth cones induced by neurotransmitters

1 reference

12 December 2020

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1 reference

12 December 2020

Dose-dependent protective effects of apomorphine against methamphetamine-induced nigrostriatal damage

1 reference

12 December 2020

Oxidative stress and the pathogenesis of Parkinson's disease

1 reference

12 December 2020

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

1 reference

12 December 2020

Long term amantadine treatment. The danger of withdrawal

1 reference

12 December 2020

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

12 December 2020

Neuroprotection by the inhibition of apoptosis

1 reference

12 December 2020

Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures

1 reference

12 December 2020

Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease

1 reference

12 December 2020

Pramipexole reduces reactive oxygen species production in vivo and in vitro and inhibits the mitochondrial permeability transition produced by the parkinsonian neurotoxin methylpyridinium ion.

1 reference

12 December 2020

Partially protective effect of amantadine in the MPTP model of Parkinson's disease

1 reference

12 December 2020

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons

1 reference

12 December 2020

cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

1 reference

12 December 2020

Use of desferrioxamine in the treatment of aceruloplasminemia

1 reference

12 December 2020

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence

1 reference

12 December 2020

Use of 6-hydroxydopamine to create lesions in catecholamine neurons in rats

1 reference

12 December 2020

Long-term evaluation of amantadine and levodopa combination in parkinsonism by double-blind corssover analyses

1 reference

12 December 2020

Transdermal nicotine in PD: a randomized, double-blind, placebo-controlled study

1 reference

12 December 2020

Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience

1 reference

12 December 2020

Apomorphine up-regulates NGF and GDNF synthesis in cultured mouse astrocytes

1 reference

12 December 2020

Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages

1 reference

12 December 2020

10.2165/00023210-200317100-00004

Identifiers

DOI

1 reference

PubMed ID

12873156

Dimensions Publication ID

7 August 2017

0 references

1 reference

PubMed ID

12873156