(Q35215989)

7 August 2017

Activators of PKM2 in cancer metabolism (English)

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7 August 2017

3

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7 August 2017

Steven L Warner

1

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PubMed ID

25078136

7 August 2017

Kent J Carpenter

series ordinal

2

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7 August 2017

1 June 2014

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Future Medicinal Chemistry

7 August 2017

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7 August 2017

6

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7 August 2017

1167-1178

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7 August 2017

10

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On the Origin of Cancer Cells

7 August 2017

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

21 January 2018

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Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

21 January 2018

1 reference

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

21 January 2018

1 reference

Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization

21 January 2018

1 reference

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

21 January 2018

1 reference

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

21 January 2018

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Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells

21 January 2018

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

21 January 2018

1 reference

Pyruvate kinase activity and isozyme composition in normal fibrous tissue and fibroblastic proliferations

21 January 2018

1 reference

MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells

21 January 2018

1 reference

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

21 January 2018

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Genetic selection for enhanced serine metabolism in cancer development.

21 January 2018

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

21 January 2018

1 reference

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

21 January 2018

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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

21 January 2018

1 reference

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

1 reference

Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus

21 January 2018

1 reference

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

1 reference

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

21 January 2018

1 reference

Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells

21 January 2018

1 reference

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

21 January 2018

1 reference

Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

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Nuclear PKM2 regulates the Warburg effect.

21 January 2018

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

21 January 2018

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Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.

21 January 2018

1 reference

Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

21 January 2018

1 reference

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

21 January 2018

1 reference

Nuclear PKM2 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma

21 January 2018

1 reference

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

21 January 2018

1 reference

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

21 January 2018

1 reference

Identification of small molecule inhibitors of pyruvate kinase M2

21 January 2018

1 reference

Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells

21 January 2018

1 reference

Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

21 January 2018

1 reference

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

21 January 2018

1 reference

Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2).

21 January 2018

1 reference

Pharmacologic activation of PKM2 slows lung tumor xenograft growth.

21 January 2018

1 reference

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

21 January 2018

1 reference

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

21 January 2018

1 reference

Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

21 January 2018

1 reference

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

1 reference

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

1 reference

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

1 reference

1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.14.70

1 reference

7 August 2017

1 reference

PubMed ID

25078136