(Q35229337)

7 August 2017

title

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. (English)

1 reference

7 August 2017

0 references

4

John J Irwin

0 references

Brian K. Shoichet

5

Brian K Shoichet

0 references

Avner Schlessinger

1

Avner Schlessinger

0 references

Andrej Šali

7

Andrej Sali

0 references

Avner Schlessinger

1

Avner Schlessinger

1 reference

7 August 2017

2

Ethan Geier

1 reference

7 August 2017

Hao Fan

3

1 reference

7 August 2017

Kathleen M Giacomini

6

1 reference

7 August 2017

language of work or name

English

0 references

publication date

1 September 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

published in

1 reference

7 August 2017

volume

108

1 reference

7 August 2017

issue

38

1 reference

7 August 2017

page(s)

15810-15815

1 reference

ModBase, a database of annotated comparative protein structure models, and associated resources

7 August 2017

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27 July 2018

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27 July 2018

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Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family

27 July 2018

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

27 July 2018

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Relating protein pharmacology by ligand chemistry

27 July 2018

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Active sugar transport in health and disease

27 July 2018

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27 July 2018

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The functional impact of SLC6 transporter genetic variation

27 July 2018

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Lessons from lactose permease

27 July 2018

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Hierarchical docking of databases of multiple ligand conformations

27 July 2018

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27 July 2018

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Virtual screening of chemical libraries

27 July 2018

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

27 July 2018

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Inhibition of dopamine beta oxidase by adrenalone

27 July 2018

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Clinical experience with DBI (phenformin) in the management of diabetes

27 July 2018

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In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Structure-based strategies for drug design and discovery

27 July 2018

1 reference

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Sodium-coupled neurotransmitter transporters

27 July 2018

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Unlocking the molecular secrets of sodium-coupled transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106030108

Structure and function of Na(+)-symporters with inverted repeats

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1106030108

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106030108

A competitive inhibitor traps LeuT in an open-to-out conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106030108

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site

21 January 2018

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DrugBank: a comprehensive resource for in silico drug discovery and exploration

21 January 2018

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Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease

21 January 2018

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The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106030108

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1106030108

Automated docking screens: a feasibility study

21 January 2018

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Rapid context-dependent ligand desolvation in molecular docking

21 January 2018

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Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

21 January 2018

1 reference

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Ligand-supported Homology Modelling of Protein Binding-sites using Knowledge-based Potentials

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1106030108

Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury

21 January 2018

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BINDING AND RELEASE OF METARAMINOL: MECHANISM OF NOREPINEPHRINE DEPLETION BY ALPHA-METHYL-M-TYROSINE AND RELATED AGENTS.

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179104

Phenformin and lactic acidosis

26 September 2018

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12 December 2020

Reduction by phenformin of excessive insulin levels after glucose loading in obese and diabetic subjects

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12 December 2020

Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer

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12 December 2020

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1106030108

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference