(Q35301222)

25281741

7 August 2017

title

Identification of small molecule inhibitors of pre-mRNA splicing. (English)

1 reference

7 August 2017

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Angus Lamond

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Andrea Pawellek

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Stuart McElroy

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Timur Samatov

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Lee Mitchell

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Andrew Woodland

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Ursula Ryder

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Reinhard Lührmann

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

0 references

publication date

3 October 2014

1 reference

25281741

7 August 2017

number of pages

16

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

50

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

34683-34698

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

4 June 2020

cites work

1 reference

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Test-firing ammunition for spliceosome inhibition in cancer

12 July 2018

1 reference

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A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes

12 July 2018

1 reference

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The spliceosome as a target of novel antitumour drugs

12 July 2018

1 reference

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Cajal bodies: where form meets function

12 July 2018

1 reference

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Alternative splicing in human tumour viruses: a therapeutic target?

12 July 2018

1 reference

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The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B

12 July 2018

1 reference

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Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay

12 July 2018

1 reference

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A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis

12 July 2018

1 reference

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Biological validation that SF3b is a target of the antitumor macrolide pladienolide

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

A stereoselective synthesis of (+)-herboxidiene/GEX1A.

12 July 2018

1 reference

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Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

The spliceosome: design principles of a dynamic RNP machine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis

12 July 2018

1 reference

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The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

12 July 2018

1 reference

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Searching for a wrench to throw into the splicing machine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

A sequence motif in the simian virus 40 (SV40) early core promoter affects alternative splicing of transcribed mRNA.

12 July 2018

1 reference

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UV-induced fragmentation of Cajal bodies.

12 July 2018

1 reference

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RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation

12 July 2018

1 reference

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Alternative splicing: a new drug target of the post-genome era.

12 July 2018

1 reference

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The spliceosome: a novel multi-faceted target for therapy

12 July 2018

1 reference

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Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

12 July 2018

1 reference

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Single base-pair substitutions in exon-intron junctions of human genes: nature, distribution, and consequences for mRNA splicing

12 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.590976

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.590976

Isolation of an active step I spliceosome and composition of its RNP core.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.590976

Golgi bypass: skirting around the heart of classical secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.590976

A pragmatic approach to the analysis of DNA histograms with a definable G1 peak

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.590976

Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263873

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

26 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.590976

Splicing-dependent and -independent modes of assembly for intron-encoded box C/D snoRNPs in mammalian cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25281741

12 December 2020

inferred from PubMed ID database lookup

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25281741

12 December 2020

inferred from PubMed ID database lookup

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25281741

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M114.590976

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25281741%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25281741

1 reference