(Q35532902)

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Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

scientific article published on 25 August 2011

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scholarly article

1 reference

Europe PubMed Central

8 August 2017

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

8 August 2017

Alzheimer's disease

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1 reference

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2

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Maria Manczak

1 reference

Europe PubMed Central

8 August 2017

author name string

Marcus J Calkins

1

1 reference

Europe PubMed Central

8 August 2017

Peizhong Mao

3

1 reference

Europe PubMed Central

8 August 2017

Ulziibat Shirendeb

4

1 reference

Europe PubMed Central

8 August 2017

P Hemachandra Reddy

5

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Europe PubMed Central

8 August 2017

publication date

25 August 2011

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Europe PubMed Central

8 August 2017

Human Molecular Genetics

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Europe PubMed Central

8 August 2017

20

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Europe PubMed Central

8 August 2017

4515-4529

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Europe PubMed Central

8 August 2017

23

1 reference

Europe PubMed Central

8 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3209824/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

1 reference

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Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

1 reference

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The interplay between mitochondrial dynamics and mitophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function

1 reference

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Tau reduction prevents Abeta-induced defects in axonal transport.

1 reference

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Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease

1 reference

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The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

1 reference

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Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons

1 reference

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The Alzheimer's disease mitochondrial cascade hypothesis

1 reference

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12 July 2018

Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline

1 reference

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Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution

1 reference

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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

1 reference

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Intracellular amyloid-beta in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

A beta oligomers - a decade of discovery

1 reference

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12 July 2018

Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

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12 July 2018

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

1 reference

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12 July 2018

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

1 reference

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12 July 2018

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

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12 July 2018

A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease

1 reference

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12 July 2018

Alzheimer's disease is a synaptic failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Alzheimer's disease: genes, proteins, and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

12 July 2018

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Regional variability and postsynaptic targets of chandelier cells in the hippocampal formation of the rat.

1 reference

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In situ localization of mitochondrial DNA replication in intact mammalian cells

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Cytochrome oxidase: an endogenous metabolic marker for neuronal activity

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Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease

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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

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26 September 2018

Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the β-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

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Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria

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Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

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26 September 2018

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

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26 September 2018

Axonal mitochondrial transport and potential are correlated

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26 September 2018

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

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26 September 2018

The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post-mortem brains

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A novel approach for studying endogenous abeta processing using cultured primary neurons isolated from APP transgenic mice

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26 September 2018

Mitochondrial abnormalities in Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209824

26 September 2018

Characterization of the Drosophila melanogaster genome at the nuclear lamina.

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21 January 2018

Application of high throughput perfusion micro 3-D cell culture platform for the precise study of cellular responses to extracellular conditions -effect of serum concentrations on the physiology of articular chondrocytes

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https://pubmed.ncbi.nlm.nih.gov/21873260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21873260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDR381

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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