(Q35535953)

8 August 2017

title

Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors (English)

1 reference

8 August 2017

15

Razelle Kurzrock

1 reference

Apostolia Maria Tsimberidou

8 August 2017

7

object named as

Apostolia M Tsimberidou

1 reference

8 August 2017

5

Aung Naing

1 reference

8 August 2017

1

Filip Janku

1 reference

8 August 2017

David S Hong

2

1 reference

8 August 2017

Siqing Fu

3

1 reference

8 August 2017

Sarina A Piha-Paul

4

1 reference

8 August 2017

Gerald S Falchook

6

1 reference

8 August 2017

Vanda M Stepanek

8

1 reference

8 August 2017

Stacy L Moulder

9

1 reference

8 August 2017

J Jack Lee

10

1 reference

8 August 2017

Rajyalakshmi Luthra

11

1 reference

8 August 2017

Ralph G Zinner

12

1 reference

8 August 2017

Russell R Broaddus

13

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8 August 2017

Jennifer J Wheler

14

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8 August 2017

language of work or name

1 reference

16 January 2014

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8 August 2017

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8 August 2017

volume

6

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8 August 2017

issue

2

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8 August 2017

page(s)

377-387

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PIK3CA mutations in advanced cancers: characteristics and outcomes

8 August 2017

cites work

1 reference

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27 July 2018

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PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative

27 July 2018

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Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

27 July 2018

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Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

27 July 2018

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Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent

27 July 2018

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PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs

27 July 2018

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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

27 July 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

27 July 2018

1 reference

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PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations

27 July 2018

1 reference

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BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

27 July 2018

1 reference

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

27 July 2018

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

27 July 2018

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

27 July 2018

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Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

27 July 2018

1 reference

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Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

27 July 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

27 July 2018

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Application of COLD-PCR for improved detection of KRAS mutations in clinical samples

27 July 2018

1 reference

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

27 July 2018

1 reference

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Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

27 July 2018

1 reference

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PTEN-deficient cancers depend on PIK3CB.

27 July 2018

1 reference

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Cancer-specific mutations in PIK3CA are oncogenic in vivo

27 July 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

27 July 2018

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

27 July 2018

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

27 July 2018

1 reference

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BRAF inhibition in refractory hairy-cell leukemia.

27 July 2018

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BRAF mutations in advanced cancers: clinical characteristics and outcomes

26 September 2018

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A phase I trial of liposomal doxorubicin, bevacizumab, and temsirolimus in patients with advanced gynecologic and breast malignancies

26 September 2018

1 reference

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PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409143

10.1016/J.CELREP.2013.12.035

26 September 2018

Identifiers

DOI

1 reference

8 August 2017

1 reference

8 August 2017

1 reference