(Q35557449)

8 August 2017

title

Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor (English)

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8 August 2017

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Charles E Frost

1

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8 August 2017

Wonkyung Byon

2

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8 August 2017

Yan Song

3

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8 August 2017

Jessie Wang

4

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8 August 2017

Alan E Schuster

5

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8 August 2017

Rebecca A Boyd

6

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8 August 2017

Donglu Zhang

7

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8 August 2017

Zhigang Yu

8

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8 August 2017

Clapton Dias

9

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8 August 2017

Andrew Shenker

10

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8 August 2017

Frank LaCreta

11

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8 August 2017

language of work or name

English

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publication date

1 May 2015

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British Journal of Clinical Pharmacology

8 August 2017

published in

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8 August 2017

volume

79

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8 August 2017

issue

5

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8 August 2017

page(s)

838-846

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Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects

8 August 2017

cites work

1 reference

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Characterization of efflux transporters involved in distribution and disposition of apixaban.

12 July 2018

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Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects

12 July 2018

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12 July 2018

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Apixaban versus warfarin in patients with atrial fibrillation

12 July 2018

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Apixaban in patients with atrial fibrillation

12 July 2018

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Apixaban versus enoxaparin for thromboprophylaxis after hip replacement

12 July 2018

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Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial

12 July 2018

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Membrane transporters in drug development

12 July 2018

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Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on th

12 July 2018

1 reference

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Apixaban or enoxaparin for thromboprophylaxis after knee replacement

12 July 2018

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Apixaban metabolism and pharmacokinetics after oral administration to humans

12 July 2018

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Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

12 July 2018

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Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood [...]

12 July 2018

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

12 July 2018

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The human intestinal cytochrome P450 "pie".

12 July 2018

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Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

12 July 2018

1 reference

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Pharmacokinetics of a Novel Diltiazem HCl Extended‐Release Tablet Formulation for Evening Administration

12 July 2018

1 reference

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Clinical importance of the cytochromes P450

12 July 2018

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The drug efflux-metabolism alliance: biochemical aspects.

12 July 2018

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Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.

12 July 2018

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Grapefruit juice-drug interactions

12 July 2018

1 reference

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415720

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415720

Clinical pharmacokinetics of ketoconazole

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415720

Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415720

Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

12 July 2018

1 reference

Oral apixaban for the treatment of acute venous thromboembolism

21 January 2018

1 reference

In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies

21 January 2018

1 reference

Tissue Distribution and Elimination of [14C]Apixaban in Rats

21 January 2018

1 reference

Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.

21 January 2018

1 reference

Sulfation of o-demethyl apixaban: enzyme identification and species comparison

21 January 2018

1 reference

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

21 January 2018

1 reference

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

Effect of different durations of ketoconazole dosing on the single-dose pharmacokinetics of midazolam: shortening the paradigm

21 January 2018

1 reference

Comparison of midazolam and simvastatin as cytochrome P450 3A probes

21 January 2018

1 reference

Apixaban for extended treatment of venous thromboembolism

21 January 2018

1 reference

12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

1 reference

12 December 2020

Factor Xa--a promising target for drug development

1 reference

12 December 2020

Warfarin and Phenytoin Interaction

1 reference

12 December 2020

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein

1 reference

12 December 2020

LC-MS/MS determination of apixaban (BMS-562247) and its major metabolite in human plasma: an application of polarity switching and monolithic HPLC column

1 reference

12 December 2020

St John's Wort: effect on CYP3A4 activity

1 reference

12 December 2020

Potentiation of warfarin action by miconazole oral gel

1 reference

12 December 2020

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

1 reference

12 December 2020

Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation

1 reference

12 December 2020

Identifiers

DOI

10.1111/BCP.12541

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8 August 2017

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8 August 2017

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