(Q35563126)

8 August 2017

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title

Multiple roles of the tuberous sclerosis complex genes (English)

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8 August 2017

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tumor suppressor gene

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14566857

22 March 2024

1 reference

22 March 2024

author name string

Raymond S. Yeung

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14566857

22 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14566857

22 March 2024

publication date

1 December 2003

1 reference

full work available at URL

8 August 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgcc.10256

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https://onlinelibrary.wiley.com/doi/pdf/10.1002/gcc.10256

22 March 2024

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Genes, Chromosomes and Cancer

22 March 2024

published in

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8 August 2017

38

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8 August 2017

4

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8 August 2017

368-375

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Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis

8 August 2017

1 reference

7 January 2021

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

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7 January 2021

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

1 reference

7 January 2021

Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect

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7 January 2021

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

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7 January 2021

Apparent preferential loss of heterozygosity at TSC2 over TSC1 chromosomal region in tuberous sclerosis hamartomas

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7 January 2021

New developments in the neurobiology of the tuberous sclerosis complex

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7 January 2021

Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology

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7 January 2021

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

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7 January 2021

Clinical development of mammalian target of rapamycin inhibitors

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7 January 2021

Identification and characterization of the tuberous sclerosis gene on chromosome 16

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7 January 2021

Akt participation in the Wnt signaling pathway through Dishevelled

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7 January 2021

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

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7 January 2021

Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains

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7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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7 January 2021

The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor

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7 January 2021

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

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7 January 2021

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

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7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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7 January 2021

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

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7 January 2021

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

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7 January 2021

Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.

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7 January 2021

Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

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7 January 2021

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer

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7 January 2021

The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape

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7 January 2021

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

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7 January 2021

Regulation of TSC2 by 14-3-3 binding

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7 January 2021

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

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7 January 2021

The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

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7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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7 January 2021

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

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7 January 2021

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways

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7 January 2021

The promise and perils of Wnt signaling through beta-catenin.

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7 January 2021

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

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7 January 2021

Loss of tuberin, the tuberous-sclerosis-complex-2 gene product is associated with angiogenesis

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7 January 2021

A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis

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7 January 2021

Increasingly complex: new players enter the Wnt signaling network

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7 January 2021

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase

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7 January 2021

Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors

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7 January 2021

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

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7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

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7 January 2021

Wnt signalling sees spots.

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7 January 2021

The TOR kinases link nutrient sensing to cell growth

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7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

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7 January 2021

Caveolin-1 Potentiates Estrogen Receptor α (ERα) Signaling

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7 January 2021

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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7 January 2021

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin

1 reference

7 January 2021

Lipid rafts and signal transduction

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7 January 2021

Caveolins, liquid-ordered domains, and signal transduction

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7 January 2021

Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

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7 January 2021

Genetic control of cell size

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7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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7 January 2021

Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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7 January 2021

Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4.

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7 January 2021

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

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7 January 2021

Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin

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7 January 2021

Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10

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7 January 2021

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

1 reference

7 January 2021

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.

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7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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7 January 2021

Hereditary renal adenomas and adenocarcinomas in rats

12

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Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions

22 March 2024

22

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Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors

22 March 2024

28

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22 March 2024

Identifiers

DOI

10.1002/GCC.10256

1 reference

release_qtf557sufbbtni2lokw5ibiq2u

8 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/qtf557sufbbtni2lokw5ibiq2u

24 November 2022

mapped directly with Wikidata item

1 reference