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NF2: the wizardry of merlin
scientific article published on December 2003
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
NF2: the wizardry of merlin
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
author
Jonathan Chernoff
object named as
Jonathan Chernoff
series ordinal
2
0 references
author name string
Guang-Hui Xiao
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
Joseph R Testa
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
publication date
1 December 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
published in
Genes, Chromosomes and Cancer
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
volume
38
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
page(s)
389-399
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
cites work
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
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Neurofibromatosis 2 and malignant mesothelioma
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The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells
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Crossref
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https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
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High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas
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Crossref
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https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERM proteins and merlin: integrators at the cell cortex
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Crossref
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7 January 2021
based on heuristic
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Stat3 as an oncogene
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7 January 2021
based on heuristic
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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromatosis type 2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rac1 mediates STAT3 activation by autocrine IL-6
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
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Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
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Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
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inferred from DOI database lookup
Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromatosis 2: loss of merlin's protective spell
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
The neurofibromatoses: when less is more
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rho GTPases and the actin cytoskeleton
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation and cancer: statistical study of retinoblastoma
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Crossref
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https://api.crossref.org/works/10.1002%2FGCC.10282
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7 January 2021
based on heuristic
inferred from DOI database lookup
Asbestos and mesothelioma: genetic lessons from a tragedy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two genetic hits (more or less) to cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of the Rho family GTPases in Ras-stimulated Raf activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Merlin suppresses the SRE-dependent transcription by inhibiting the activation of Ras-ERK pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rho GTPases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras and Rho regulation of the cell cycle and oncogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
EPS8 and E3B1 transduce signals from Ras to Rac
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interdomain binding mediates tumor growth suppression by the NF2 gene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CDK inhibitors: positive and negative regulators of G1-phase progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of STAT3 by direct binding to the Rac1 GTPase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERM proteins: head-to-tail regulation of actin-plasma membrane interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p21-activated kinase links Rac/Cdc42 signaling to merlin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Merlin differentially associates with the microtubule and actin cytoskeleton
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytological and cytogenetical studies on human meningioma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.10282
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/GCC.10282
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
PubMed ID
14566860
1 reference
stated in
Europe PubMed Central
PubMed ID
14566860
retrieved
8 August 2017
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