(Q35566353)

8 August 2017

1 reference

title

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms (English)

1 reference

8 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14574440

24 March 2024

1 reference

https://api.crossref.org/works/10.1007/S00210-003-0819-Z

24 March 2024

author

Magnus Ingelman-Sundberg

series ordinal

1

object named as

Magnus Ingelman-Sundberg

0 references

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14574440

24 March 2024

publication date

22 October 2003

1 reference

full work available at URL

8 August 2017

http://link.springer.com/content/pdf/10.1007/s00210-003-0819-z.pdf

file format

Portable Document Format

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00210-003-0819-Z

http://link.springer.com/article/10.1007/s00210-003-0819-z/fulltext.html

24 March 2024

1 reference

https://api.crossref.org/works/10.1007/S00210-003-0819-Z

http://link.springer.com/content/pdf/10.1007/s00210-003-0819-z

24 March 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00210-003-0819-Z

Naunyn-Schmiedeberg's Archives of Pharmacology

24 March 2024

published in

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8 August 2017

369

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8 August 2017

89-104

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8 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1007/s00210-003-0819-z

8 August 2017

0 references

cites work

Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity

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12 December 2020

Study of P450 function using gene knockout and transgenic mice

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12 December 2020

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

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12 December 2020

Characterization and functional analysis of two common human cytochrome P450 1B1 variants

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12 December 2020

Detection and characterization of novel polymorphisms in the CYP2E1 gene

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12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

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12 December 2020

Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene

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12 December 2020

Further characterization of the expression in liver and catalytic activity of CYP2B6.

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12 December 2020

Inheritance and drug response

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12 December 2020

The role of CYP2B6 in human xenobiotic metabolism

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12 December 2020

trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines

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12 December 2020

Detection of single nucleotide polymorphisms in CYP2B6 gene

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12 December 2020

Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase

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12 December 2020

The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.

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12 December 2020

Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1

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12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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12 December 2020

Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells

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12 December 2020

Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

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12 December 2020

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

1 reference

12 December 2020

Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).

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12 December 2020

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

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12 December 2020

Zonation of hepatic cytochrome P-450 expression and regulation

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12 December 2020

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

1 reference

12 December 2020

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

1 reference

12 December 2020

Characterization of human small intestinal cytochromes P-450.

1 reference

12 December 2020

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

1 reference

12 December 2020

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

1 reference

12 December 2020

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

1 reference

12 December 2020

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking

1 reference

12 December 2020

Evidence of proteasome-mediated cytochrome P-450 degradation

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens

1 reference

12 December 2020

Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase

1 reference

12 December 2020

Catalytic properties of polymorphic human cytochrome P450 1B1 variants.

1 reference

12 December 2020

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

1 reference

12 December 2020

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

1 reference

12 December 2020

Involvement of human liver cytochrome P4502B6 in the metabolism of propofol

1 reference

12 December 2020

In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues

1 reference

12 December 2020

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

1 reference

12 December 2020

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

1 reference

12 December 2020

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

1 reference

12 December 2020

Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells

1 reference

12 December 2020

Physiological parameters in laboratory animals and humans

1 reference

12 December 2020

Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver

1 reference

12 December 2020

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

12 December 2020

Human CYP2B6: expression, inducibility and catalytic activities

1 reference

12 December 2020

Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer

1 reference

12 December 2020

An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant

1 reference

12 December 2020

CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver

1 reference

12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

1 reference

12 December 2020

In vitro and pharmacophore insights into CYP3A enzymes

1 reference

12 December 2020

Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans

1 reference

12 December 2020

Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).

1 reference

12 December 2020

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

12 December 2020

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1 reference

12 December 2020

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir

1 reference

12 December 2020

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

1 reference

12 December 2020

Functional characterization of cytochrome P450 2B6 allelic variants

1 reference

12 December 2020

Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions

1 reference

12 December 2020

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

1 reference

12 December 2020

In vitro and in vivo drug interactions involving human CYP3A.

1 reference

12 December 2020

Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes.

1 reference

12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line

1 reference

12 December 2020

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

1 reference

12 December 2020

Human cytochrome P450 (CYP) genes: recommendations for the nomenclature of alleles.

1 reference

12 December 2020

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

1 reference

12 December 2020

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

1 reference

12 December 2020

Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review

1 reference

12 December 2020

Transcriptional and post-translational regulation of CYP1A1 by primaquine

1 reference

12 December 2020

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

1 reference

12 December 2020

Competitive CYP2C9 inhibitors: enzyme inhibition studies, protein homology modeling, and three-dimensional quantitative structure-activity relationship analysis

1 reference

12 December 2020

Transcriptional control of CYP2E1 in the perivenous liver region and during starvation.

1 reference

12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

1 reference

12 December 2020

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

1 reference

12 December 2020

Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21

1 reference

12 December 2020

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1 reference

12 December 2020

Identification and functional characterization of eight CYP3A4 protein variants

1 reference

12 December 2020

A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function.

1 reference

12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

12 December 2020

Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1.

1 reference

12 December 2020

Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy

1 reference

12 December 2020

Genetic polymorphism of human CYP2E1: characterization of two variant alleles

1 reference

12 December 2020

Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

1 reference

12 December 2020

CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes

1 reference

12 December 2020

Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles.

1 reference

12 December 2020

Molecular Basis for the Transport of Cytochrome P450 2E1 to the Plasma Membrane

1 reference

12 December 2020

Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation.

1 reference

12 December 2020

Tumor-specific expression of cytochrome P450 CYP1B1.

1 reference

12 December 2020

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture

1 reference

12 December 2020

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

1 reference

12 December 2020

Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1.

1 reference

12 December 2020

Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization

1 reference

12 December 2020

Inhibition and induction of human cytochrome P450 (CYP) enzymes

1 reference

12 December 2020

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

1 reference

12 December 2020

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

1 reference

12 December 2020

Isolation and characterization of the human cytochrome P450 CYP1B1 gene

1 reference

12 December 2020

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation

1 reference

12 December 2020

Expression of cytochrome P450 CYP1B1 in breast cancer

1 reference

12 December 2020

Cytochrome P450 3A: ontogeny and drug disposition

1 reference

12 December 2020

Identification of a novel dioxin-inducible cytochrome P450.

1 reference

12 December 2020

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

12 December 2020

The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.

1 reference

12 December 2020

Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

1 reference

12 December 2020

Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

1 reference

12 December 2020

Carbamazepine: a 'blind' assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems

1 reference

12 December 2020

Genotype???phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women

1 reference

12 December 2020

Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

1 reference

12 December 2020

Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population

1 reference

12 December 2020

A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake

1 reference

12 December 2020

Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome p450s: evidence for involvement in host-plant allelochemical resistance

1 reference

12 December 2020

Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation

1 reference

12 December 2020

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

1 reference

12 December 2020

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

12 December 2020

Examination of purported probes of human CYP2B6.

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

1 reference

12 December 2020

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

1 reference

12 December 2020

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

12 December 2020

Identifiers

DOI

1 reference

8 August 2017

1 reference