(Q35577695)

9 August 2017

1 reference

title

The Werner syndrome helicase-nuclease--one protein, many mysteries (English)

1 reference

9 August 2017

The Werner Syndrome Helicase-Nuclease--One Protein, Many Mysteries (English)

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

1 reference

Michael Fry

1

1 reference

9 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14602980

29 March 2024

publication date

3 April 2002

1 reference

full work available at URL

9 August 2017

https://www.science.org/doi/pdf/10.1126/sageke.2002.13.re2

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Science of aging knowledge environment : SAGE KE

29 March 2024

published in

1 reference

9 August 2017

volume

2002

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9 August 2017

issue

13

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9 August 2017

page(s)

re2

1 reference

Extension of life-span by introduction of telomerase into normal human cells

9 August 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.279.5349.349

The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases

1

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome protein: biochemical properties and functional interactions

29 March 2024

2

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Werner syndrome protein: an update

29 March 2024

3

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

Helicases and aging

4

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Human Genome and Diseases: A new series of reviews in CMLS Werner Syndrome: genetic and molecular basis of a premature aging disorder

29 March 2024

5

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

29 March 2024

6

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Unwinding the molecular basis of the Werner syndrome

29 March 2024

7

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

29 March 2024

9

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts

29 March 2024

10

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The gene responsible for Werner syndrome may be a cell division "counting" gene

29 March 2024

11

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Genetic linkage of Werner's syndrome to five markers on chromosome 8

29 March 2024

14

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Positional cloning of the Werner's syndrome gene

29 March 2024

15

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Werner syndrome protein is a DNA helicase

29 March 2024

16

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

29 March 2024

17

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

29 March 2024

18

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

29 March 2024

19

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication

29 March 2024

21

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

29 March 2024

22

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

29 March 2024

23

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Escherichia coli RecQ protein is a DNA helicase

29 March 2024

25

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

29 March 2024

26

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

29 March 2024

27

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Replication focus-forming activity 1 and the Werner syndrome gene product

29 March 2024

28

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization

29 March 2024

29

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Structure and function of the human Werner syndrome gene promoter: evidence for transcriptional modulation

29 March 2024

30

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

WRN mutations in Werner syndrome

29 March 2024

31

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

29 March 2024

32

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

DNA helicases, genomic instability, and human genetic disease

29 March 2024

33

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Bloom's syndrome gene product is homologous to RecQ helicases

29 March 2024

34

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

29 March 2024

35

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

29 March 2024

36

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

29 March 2024

37

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

29 March 2024

38

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

29 March 2024

39

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

29 March 2024

40

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Bloom's syndrome helicase unwinds G4 DNA

29 March 2024

42

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Bloom's syndrome gene product promotes branch migration of holliday junctions

29 March 2024

43

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

29 March 2024

44

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

29 March 2024

45

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

29 March 2024

46

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

29 March 2024

47

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

29 March 2024

48

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

29 March 2024

49

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Characterization of the human and mouse WRN 3'-->5' exonuclease

29 March 2024

51

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

29 March 2024

52

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.

29 March 2024

53

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

29 March 2024

54

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

29 March 2024

55

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner protein recruits DNA polymerase delta to the nucleolus

29 March 2024

56

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

29 March 2024

57

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence

29 March 2024

58

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

29 March 2024

60

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Functional and physical interaction between WRN helicase and human replication protein A

29 March 2024

61

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.

29 March 2024

62

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Enzymes and reactions at the eukaryotic DNA replication fork

29 March 2024

63

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

29 March 2024

64

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events

29 March 2024

65

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

29 March 2024

66

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

29 March 2024

67

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

29 March 2024

68

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle

29 March 2024

69

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Ku, a DNA repair protein with multiple cellular functions?

29 March 2024

70

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Functional interaction between Ku and the werner syndrome protein in DNA end processing

29 March 2024

72

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

29 March 2024

73

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

29 March 2024

74

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

29 March 2024

75

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Regulation of cellular senescence by p53.

29 March 2024

76

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors

29 March 2024

77

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

p53-mediated apoptosis is attenuated in Werner syndrome cells

29 March 2024

78

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Werner syndrome protein contributes to induction of p53 by DNA damage

29 March 2024

79

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

29 March 2024

80

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Physical and functional interaction between p53 and the Werner's syndrome protein

29 March 2024

81

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

p53 Modulates the exonuclease activity of Werner syndrome protein

29 March 2024

82

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

p53 mutant mice that display early ageing-associated phenotypes

29 March 2024

83

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

84

61

1816

2001

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

29 March 2024

85

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

A novel protein interacts with the Werner's syndrome gene product physically and functionally

29 March 2024

86

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

29 March 2024

87

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein

29 March 2024

88

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage

29 March 2024

89

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Cytogenetics and Cell Genetics

29 March 2024

90

17

100

1975

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

In vivo somatic mutations in Werner's syndrome

29 March 2024

91

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

92

60

2492

2000

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome

29 March 2024

93

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Spontaneous and induced chromosomal instability in Werner syndrome

29 March 2024

94

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

29 March 2024

95

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

96

60

2372

2000

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

DNA repair fine structure in Werner's syndrome cell lines.

29 March 2024

98

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

99

60

2956

1997

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

29 March 2024

100

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

29 March 2024

101

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Loss of Werner syndrome protein function promotes aberrant mitotic recombination

29 March 2024

102

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Transcriptional activation by the Werner syndrome gene product in yeast

29 March 2024

103

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Werner syndrome protein is involved in RNA polymerase II transcription

29 March 2024

104

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Werner helicase is localized to transcriptionally active nucleoli of cycling cells

29 March 2024

105

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Nucleolar localization of the Werner syndrome protein in human cells

29 March 2024

106

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Diverged nuclear localization of Werner helicase in human and mouse cells

29 March 2024

107

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts

29 March 2024

108

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Telomere length predicts replicative capacity of human fibroblasts

29 March 2024

109

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo

29 March 2024

110

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

29 March 2024

111

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

29 March 2024

113

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus

29 March 2024

114

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

29 March 2024

115

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

29 March 2024

116

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

29 March 2024

118

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

Lessons from human progeroid syndromes

29 March 2024

119

1 reference

https://api.crossref.org/works/10.1126/SAGEKE.2002.13.RE2

29 March 2024

Identifiers

1 reference

9 August 2017

1 reference