(Q35580690)

9 August 2017

1 reference

title

Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex (English)

1 reference

lipopolysaccharide immune receptor activity

9 August 2017

0 references

1 reference

1 reference

Gene Ontology release 2020-05-02

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

31 March 2024

author name string

Mitsuhiro Fujihara

1

1 reference

9 August 2017

Masashi Muroi

2

1 reference

9 August 2017

Ken-ichi Tanamoto

3

1 reference

9 August 2017

Tsuneo Suzuki

4

1 reference

9 August 2017

Hiroshi Azuma

5

1 reference

9 August 2017

Hisami Ikeda

6

1 reference

9 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14609719

31 March 2024

publication date

1 November 2003

1 reference

full work available at URL

9 August 2017

https://api.elsevier.com/content/article/PII:S0163725803001220?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

https://api.elsevier.com/content/article/PII:S0163725803001220?httpAccept=text/plain

31 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Pharmacology & Therapeutics

31 March 2024

published in

1 reference

9 August 2017

100

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9 August 2017

171-194

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9 August 2017

2

1 reference

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

9 August 2017

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/44605

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.282.5396.2085

Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression

1

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages.

31 March 2024

2

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition

31 March 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Toll-like receptors: critical proteins linking innate and acquired immunity

31 March 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

31 March 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

31 March 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

31 March 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation.

31 March 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

31 March 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.

31 March 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma : a molecular basis for priming and synergism with bacterial lipopolysaccharide

31 March 2024

12

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis.

31 March 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

31 March 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia

31 March 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

MyD88, an adapter protein involved in interleukin-1 signaling

31 March 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

31 March 2024

17

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Protection from septic shock by neutralization of macrophage migration inhibitory factor

31 March 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

31 March 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

IRAK: a kinase associated with the interleukin-1 receptor

31 March 2024

20

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

31 March 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

31 March 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction

31 March 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

E5531, a pure endotoxin antagonist of high potency

31 March 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The immunopathogenesis of sepsis

31 March 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta

31 March 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor

31 March 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition

31 March 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

31 March 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Shared actions of endotoxin and taxol on TNF receptors and TNF release

31 March 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Toll receptors, CD14, and macrophage activation and deactivation by LPS.

31 March 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components

31 March 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

31 March 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

31 March 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa

31 March 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells

31 March 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

31 March 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

NF-kappaB elements contribute to junB inducibility by lipopolysaccharide in the murine macrophage cell line RAW264.7.

31 March 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia

31 March 2024

48

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

31 March 2024

49

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

31 March 2024

50

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

31 March 2024

51

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

31 March 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

LPS induction of gene expression in human monocytes

31 March 2024

54

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ.

31 March 2024

55

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

CD14 is a cell-activating receptor for bacterial peptidoglycan

31 March 2024

56

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

31 March 2024

57

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Human Toll-like receptor 4 recognizes host-specific LPS modifications.

31 March 2024

58

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages

31 March 2024

59

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

31 March 2024

60

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

31 March 2024

61

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

31 March 2024

62

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

31 March 2024

63

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

A Toll-like receptor recognizes bacterial DNA

31 March 2024

65

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

31 March 2024

66

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

31 March 2024

69

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells

31 March 2024

70

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

TIRAP: an adapter molecule in the Toll signaling pathway

31 March 2024

71

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Regulation of IL-1 receptor-associated kinases by lipopolysaccharide

31 March 2024

73

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways

31 March 2024

74

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Human Nod1 confers responsiveness to bacterial lipopolysaccharides

31 March 2024

75

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Nods: a family of cytosolic proteins that regulate the host response to pathogens

31 March 2024

76

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

31 March 2024

77

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase.

31 March 2024

78

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages

31 March 2024

79

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.

31 March 2024

80

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Approaching the asymptote? Evolution and revolution in immunology

31 March 2024

81

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The immune system evolved to discriminate infectious nonself from noninfectious self

31 March 2024

82

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

31 March 2024

83

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88

31 March 2024

84

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64.

31 March 2024

85

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Identification of a domain in soluble CD14 essential for lipopolysaccharide (LPS) signaling but not LPS binding

31 March 2024

86

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Endotoxin-induced maturation of MyD88-deficient dendritic cells

31 March 2024

87

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

31 March 2024

88

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes

31 March 2024

89

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

31 March 2024

90

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance

31 March 2024

91

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Unresponsiveness of MyD88-deficient mice to endotoxin

31 March 2024

93

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

31 March 2024

94

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

31 March 2024

95

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Cutting edge: Gln22 of mouse MD-2 is essential for species-specific lipopolysaccharide mimetic action of taxol

31 March 2024

96

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis

31 March 2024

97

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide

31 March 2024

98

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product

31 March 2024

99

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

31 March 2024

100

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Diphosphoryl lipid A derived from lipopolysaccharide (LPS) of Rhodopseudomonas sphaeroides inhibits activation of 70Z/3 cells by LPS.

31 March 2024

101

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

31 March 2024

102

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

IRAK-M is a negative regulator of Toll-like receptor signaling

31 March 2024

104

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

31 March 2024

105

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The involvement of an LPS inducible I kappa B kinase in endotoxin tolerance

31 March 2024

106

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

31 March 2024

108

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

mRNA and protein stability regulate the differential expression of pro- and anti-inflammatory genes in endotoxin-tolerant THP-1 cells

31 March 2024

109

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Characterization of the nuclear import and export functions of Ikappa B(epsilon).

31 March 2024

110

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin

31 March 2024

111

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Two lipoproteins extracted from Escherichia coli K-12 LCD25 lipopolysaccharide are the major components responsible for Toll-like receptor 2-mediated signaling

31 March 2024

112

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

31 March 2024

113

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

31 March 2024

114

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells

31 March 2024

115

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

31 March 2024

116

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

31 March 2024

117

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

31 March 2024

118

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS.

31 March 2024

120

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia

31 March 2024

121

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia

31 March 2024

122

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses

31 March 2024

125

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression

31 March 2024

127

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.

31 March 2024

128

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells

31 March 2024

129

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Toll-like receptors and innate immunity

31 March 2024

130

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

31 March 2024

131

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

31 March 2024

132

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Interleukin-10 and the interleukin-10 receptor

31 March 2024

133

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Differential recognition of structural details of bacterial lipopeptides by toll-like receptors

31 March 2024

134

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

31 March 2024

136

1 reference

https://api.crossref.org/works/10.1016/J.PHARMTHERA.2003.08.003

Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line, J774.

31 March 2024

137

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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SOCS-1 participates in negative regulation of LPS responses

31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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CD14 is a pattern recognition receptor

31 March 2024

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Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

31 March 2024

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31 March 2024

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Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

31 March 2024

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31 March 2024

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31 March 2024

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A family of human receptors structurally related to Drosophila Toll

31 March 2024

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MIF regulates innate immune responses through modulation of Toll-like receptor 4

31 March 2024

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Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock

31 March 2024

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31 March 2024

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Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

31 March 2024

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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3

31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli.

31 March 2024

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Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

31 March 2024

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

31 March 2024

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IRAK-4 as the central TIR signaling mediator in innate immunity

31 March 2024

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IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

31 March 2024

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

31 March 2024

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Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

31 March 2024

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

31 March 2024

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Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

31 March 2024

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Predominant role of the substituents on the hydroxyl groups of 3-hydroxy fatty acids of non-reducing glucosamine in lipid A for the endotoxic and antagonistic activity

31 March 2024

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Salmonella-type heptaacylated lipid A is inactive and acts as an antagonist of lipopolysaccharide action on human line cells

31 March 2024

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Mitogenic activities of synthetic lipid A analogs and suppression of mitogenicity of lipid A.

31 March 2024

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

31 March 2024

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Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

31 March 2024

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31 March 2024

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A CD14-independent LPS receptor cluster

31 March 2024

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Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin

31 March 2024

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Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

31 March 2024

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Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

31 March 2024

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Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors

31 March 2024

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A region of human CD14 required for lipopolysaccharide binding

31 March 2024

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The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor

31 March 2024

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Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4

31 March 2024

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Clinical aspects: from systemic inflammation to 'immunoparalysis'.

31 March 2024

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

31 March 2024

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IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

31 March 2024

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CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

31 March 2024

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IL-12 Suppression During Experimental Endotoxin Tolerance: Dendritic Cell Loss and Macrophage Hyporesponsiveness

31 March 2024

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

31 March 2024

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

31 March 2024

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

31 March 2024

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A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei

31 March 2024

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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

31 March 2024

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Negative regulation of cytokine signaling pathways

31 March 2024

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CpG DNA induces self and cross-hyporesponsiveness of RAW264.7 cells in response to CpG DNA and lipopolysaccharide: alterations in IL-1 receptor-associated kinase expression

31 March 2024

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Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.

31 March 2024

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Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level

31 March 2024

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31 March 2024

Identifiers

1 reference

9 August 2017

1 reference