(Q35607534)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

review article

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title

Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

0 references

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author name string

Dion R Brocks

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

publication date

1 January 2003

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Clinical Pharmacokinetics

22 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

volume

42

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

page(s)

1359-1382

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

issue

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14674788%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.2165/00003088-200342150-00004

22 December 2019

exact match

0 references

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Enantioselective assay of chloroquine and its main metabolite deethyl chloroquine in human plasma by capillary electrophoresis

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In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum

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Stereochemical aspects of pharmacotherapy

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Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomers

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Pharmacokinetics of quinine, quinidine and Cinchonine when given as combination

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Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and -resistant plasmodium falciparum in vitro

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In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

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12 December 2020

High-performance liquid chromatographic separation of the enantiomers of hydroxychloroquine and its major metabolites in biological fluids using an α1-acid glycoprotein stationary phase

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12 December 2020

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12 December 2020

Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents

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12 December 2020

Stereochemistry in pharmacotherapy: when mirror images are not identical

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12 December 2020

The determination of the enantiomers of halofantrine and monodesbutylhalofantrine in plasma and whole blood using sequential achiral/chiral high-performance liquid chromatography

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12 December 2020

Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state.

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12 December 2020

Disposition of the enantiomers of hydroxychloroquine in patients with rheumatoid arthritis following multiple doses of the racemate

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12 December 2020

Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents

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12 December 2020

Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?

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12 December 2020

Susceptibility of Plasmodium falciparum to different doses of quinine in vivo and to quinine and quinidine in vitro in relation to chloroquine in Liberia

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12 December 2020

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Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements

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Pharmacokinetic interaction between mefloquine and ritonavir in healthy volunteers

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Blood to plasma ratio of mefloquine: interpretation and pharmacokinetic implications

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Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes

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12 December 2020

Distribution of the enantiomers of hydroxychloroquine and its metabolites in ocular tissues of the rabbit after oral administration of racemic-hydroxychloroquine

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Enantioselective analysis of chloroquine and desethylchloroquine after oral administration of racemic chloroquine

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Mechanism of cardiotoxicity of halofantrine

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Stereoselective passage of mefloquine through the blood-brain barrier in the rat.

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A liquid chromatographic assay for the stereospecific quantitative analysis of halofantrine in human plasma

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Stereoselective inhibition of renal organic cation transport in human kidney

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12 December 2020

Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols

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Binding of artemether and lumefantrine to plasma proteins and erythrocytes

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Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects

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Differential binding of the enantiomers of chloroquine and quinacrine to polynucleotides: implications for stereoselective metabolism

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12 December 2020

Case report: Retinopathy after malaria prophylaxis with chloroquine

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12 December 2020

Uptake of mefloquine enantiomers into uninfected and malaria-infected erythrocytes.

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12 December 2020

Access to hematin: the basis of chloroquine resistance.

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12 December 2020

Clinical pharmacokinetics of mefloquine

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12 December 2020

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12 December 2020

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12 December 2020

Safety of chloroquine in chemosuppression of malaria during pregnancy

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12 December 2020

Interactions in the renal and biliary elimination of digoxin: stereoselective difference between quinine and quinidine

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12 December 2020

Direct determination of the enantiomers of the antimalarial drug halofantrine and its active metabolite N-desbutylhalofantrine in human plasma

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12 December 2020

Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

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12 December 2020

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12 December 2020

Determination of the enantiomers of mefloquine in plasma and whole blood using a coupled achiral-chiral high-performance liquid chromatographic system

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12 December 2020

A comparison of the pharmacokinetic and pharmacodynamic properties of quinine and quinidine in healthy Thai males

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12 December 2020

A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine

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12 December 2020

Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers

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12 December 2020

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12 December 2020

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12 December 2020

Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand

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12 December 2020

Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum

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12 December 2020

Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding

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12 December 2020

High-performance liquid chromatographic method for the enantioselective analysis of mefloquine in plasma and urine

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12 December 2020

Disposition and absorption of hydroxychloroquine enantiomers following a single dose of the racemate.

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12 December 2020

In vitro evaluation of quinidine sensitivity in Brazilian Plasmodium falciparum isolates: comparative analysis to quinine and chloroquine

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12 December 2020

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12 December 2020

In vitro assessment of the antimalarial activity of chloroquine and its major metabolites

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12 December 2020

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12 December 2020

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12 December 2020

Comparison between concentrations of racemic mefloquine, its separate enantiomers and the carboxylic acid metabolite in whole blood serum and plasma

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12 December 2020

The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins

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12 December 2020

Pharmacokinetics of halofantrine in man: effects of food and dose size

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12 December 2020

The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase.

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12 December 2020

Evidence of transplacental passage of hydroxychloroquine in humans

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12 December 2020

Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain

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12 December 2020

Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans.

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12 December 2020

Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria.

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12 December 2020

Quantification of the individual enantiomer plasma concentrations of the candidate antimalarial agent N4-[2,6-dimethoxy-4-methyl-5-[(3-trifluoromethyl)phenoxy]-8-quinolinyl] - 1,4-pentanediamine (WR 238,605)

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12 December 2020

Pharmacokinetics and pharmacodynamics of hydroxychloroquine enantiomers in patients with rheumatoid arthritis receiving multiple doses of racemate.

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12 December 2020

In vitro effects of primaquine and primaquine metabolites on exoerythrocytic stages of Plasmodium berghei

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12 December 2020

Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons

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12 December 2020

Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1-acid glycoprotein and the binding of quinine in Malawian children

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12 December 2020

Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation

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12 December 2020

Plasma protein binding of the enantiomers of hydroxychloroquine and metabolites

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12 December 2020

Chiral chromatographic method to determine the enantiomers of halofantrine and its main chiral desbutyl metabolite in erythrocytes.

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12 December 2020

Effects of chloroquine and its enantiomers on the development of rat embryos in vitro.

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12 December 2020

Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats

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12 December 2020

Determination of hydroxychloroquine and its major metabolites in plasma using sequential achiral-chiral high-performance liquid chromatography

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12 December 2020

Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus. A new job for an old drug?

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12 December 2020

Follow-up of the susceptibility of Plasmodium falciparum to antimalarials in Gabon.

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12 December 2020

Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations

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12 December 2020

Hematologic disposition of hydroxychloroquine enantiomers

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12 December 2020

Disposition of the diastereoisomers quinine and quinidine in the ovine fetus

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12 December 2020

Enantioselective aspects of drug action and disposition: therapeutic pitfalls

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12 December 2020

Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to plasmodium falciparum malaria

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12 December 2020

Stereoselective pharmacokinetics of mefloquine in healthy Caucasians after multiple doses

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12 December 2020

Susceptibility of glucose-6-phosphate dehydrogenase deficient red cells to primaquine, primaquine enantiomers, and its two putative metabolites. II. Effect on red blood cell membrane, lipid peroxidation, MC-540 staining, and scanning electron micros

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12 December 2020

The stereoselective distribution of halofantrine enantiomers within human, dog, and rat plasma lipoproteins

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12 December 2020

Clinical pharmacokinetics of antimalarial drugs

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12 December 2020

Enantioselective pharmacokinetics of mefloquine during long-term intake of the prophylactic dose

1 reference

12 December 2020

Comparison of the Curative Antimalarial Activities and Toxicities of Primaquine and Its d and l Isomers

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12 December 2020

Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria

1 reference

12 December 2020

Absence of antimalarial activity or interaction with mefloquine enantiomers in vitro of the main human metabolite of mefloquine

1 reference

12 December 2020

Enantioselective determination of hydroxychloroquine and its major metabolites in urine and the observation of a reversal in the (+)/(-)-hydroxychloroquine ratio

1 reference

12 December 2020

Transplacental Distribution of Chloroquine in Sheep

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12 December 2020

Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa

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12 December 2020

World malaria situation in 1994. Part I. Population at risk

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12 December 2020

Neuropsychiatric problems in 2,500 long-term young travelers to the tropics

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12 December 2020