(Q35625442)

9 August 2017

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title

Coupled reductions in brain oxidative phosphorylation and synaptic function can be quantified and staged in the course of Alzheimer disease (English)

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9 August 2017

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1

Stanley I Rapoport

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9 August 2017

1 January 2003

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9 August 2017

Neurotoxicity Research

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9 August 2017

5

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9 August 2017

6

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9 August 2017

385-398

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https://scigraph.springernature.com/pub.10.1007/bf03033167

9 August 2017

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cites work

Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable

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https://api.crossref.org/works/10.1007%2FBF03033167

Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Editorial: The prevalence and malignancy of Alzheimer disease. A major killer

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded "stress test" during PET.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Electron transport chain defects in Alzheimer's disease brain.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Energy requirements for two aspects of phospholipid metabolism in mammalian brain

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

On the Regulation of the Blood-supply of the Brain

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Parametric analysis of functional neuroimages: application to a variable-rate motor task.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03033167

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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12 December 2020

Mitochondrial diseases in man and mouse

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12 December 2020

Downregulation of oxidative phosphorylation in Alzheimer disease: loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex.

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12 December 2020

Bioenergetics and glutamate excitotoxicity

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12 December 2020

Localization of cytochrome oxidase (COX) activity and COX mRNA in the hippocampus and entorhinal cortex of the monkey brain: correlation with specific neuronal pathways.

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12 December 2020

Cerebral metabolic response to passive audiovisual stimulation in patients with Alzheimer's disease and healthy volunteers assessed by PET.

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12 December 2020

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

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12 December 2020

The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy.

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12 December 2020

Functional analysis of in vivo and in organello footprinting of HeLa cell mitochondrial DNA in relationship to ATP and ethidium bromide effects on transcription.

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12 December 2020

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12 December 2020

Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease

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12 December 2020

Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease.

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12 December 2020

Genetically altered transgenic models of Alzheimer's disease.

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12 December 2020

Blood flow metabolism couple in brain.

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12 December 2020

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

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12 December 2020

Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.

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12 December 2020

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.

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12 December 2020

Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionately regulated by functional activity in neurons.

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12 December 2020

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

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12 December 2020

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12 December 2020

Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA

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12 December 2020

Mitochondrial function in brain tissue in primary degenerative dementia.

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12 December 2020

Specificity of brain activation patterns in people at genetic risk for Alzheimer disease.

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12 December 2020

Coordination of ATP production and consumption in brain: parallel regulation of cytochrome oxidase and Na+, K(+)-ATPase

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12 December 2020

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation.

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12 December 2020

Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease.

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12 December 2020

Neuronal activity and early neurofibrillary tangles in Alzheimer's disease.

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12 December 2020

Quantitative assessment of cortical synaptic density in Alzheimer's disease.

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12 December 2020

Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology.

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12 December 2020

Integrated phylogeny of the primate brain, with special reference to humans and their diseases

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12 December 2020

Mitochondrial dysfunction in neurodegenerative diseases

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12 December 2020

Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease

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12 December 2020

Markedly different ATP requirements for rRNA synthesis and mtDNA light strand transcription versus mRNA synthesis in isolated human mitochondria.

1 reference

12 December 2020

Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients.

1 reference

12 December 2020

Evolution of neuronal changes in the course of Alzheimer's disease.

1 reference

12 December 2020

Patterns of brain activation in people at risk for Alzheimer's disease.

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12 December 2020

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

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12 December 2020

Parametric in vivo brain imaging during activation to examine pathological mechanisms of functional failure in Alzheimer disease

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12 December 2020

Inflammation and Alzheimer's disease

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12 December 2020

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12 December 2020

High-resolution PET studies in Alzheimer's disease

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12 December 2020

Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.

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12 December 2020

Regulation of mitochondrial gene expression in differentiated PC12 cells

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12 December 2020

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

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12 December 2020

Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcripts

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12 December 2020

Glutamate transmission and toxicity in Alzheimer's disease

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12 December 2020

Cytochrome oxidase: an endogenous metabolic marker for neuronal activity

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12 December 2020

Muscarinic versus nicotinic modulation of a visual task. a pet study using drug probes

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12 December 2020

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

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12 December 2020

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

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12 December 2020

Energetics of functional activation in neural tissues.

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12 December 2020

Development of a novel diffusion-based method to estimate the size of the aggregated Abeta species responsible for neurotoxicity

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12 December 2020

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

1 reference

12 December 2020

Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration.

1 reference

12 December 2020

Localization of cytochrome oxidase (COX) activity and COX mRNA in the perirhinal and superior temporal sulci of the monkey brain.

1 reference

12 December 2020

New concepts in the drug therapy of Alzheimer's disease

1 reference

12 December 2020

Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease.

1 reference

12 December 2020

Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.

1 reference

12 December 2020

Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease.

1 reference

12 December 2020

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

1 reference

12 December 2020

Positron emission tomography in Alzheimer's disease in relation to disease pathogenesis: a critical review

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12 December 2020

Time- and dose-dependent changes in neuronal activity produced by X radiation in brain slices

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12 December 2020

The mechanism and regulation of fast axonal transport

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12 December 2020

Frequency Variation of a Pattern-Flash Visual Stimulus during PET Differentially Activates Brain from Striate through Frontal Cortex

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12 December 2020

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.

1 reference

12 December 2020

Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor

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12 December 2020

Activation of cerebral blood flow during a visuoperceptual task in patients with Alzheimer-type dementia.

1 reference

12 December 2020

Synthesis and degradation of cytochrome oxidase subunit mRNAs in neurons: differential bigenomic regulation by neuronal activity

1 reference

12 December 2020

The machinery of mitochondrial inheritance and behavior

1 reference

12 December 2020

No association between Alzheimer plaques and decreased levels of cytochrome oxidase subunit mRNA, a marker of neuronal energy metabolism.

1 reference

12 December 2020

Biogenesis of mitochondria

1 reference

12 December 2020

Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's disease

1 reference

12 December 2020

Neuronal expression of nuclear and mitochondrial genes for cytochrome oxidase (CO) subunits analyzed by in situ hybridization: comparison with CO activity and protein

1 reference

12 December 2020

Interleukin-1, neuroinflammation, and Alzheimer's disease

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03033167

1 reference

9 August 2017

1 reference

PubMed ID

14715441