(Q35639868)

9 August 2017

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title

Genetic and environmental factors in the pathogenesis of Huntington's disease (English)

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9 August 2017

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Anton van Dellen

1

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9 August 2017

Anthony J Hannan

series ordinal

2

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9 August 2017

publication date

24 January 2004

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9 August 2017

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9 August 2017

volume

5

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9 August 2017

issue

1

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9 August 2017

page(s)

9-17

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https://scigraph.springernature.com/pub.10.1007/s10048-003-0169-5

9 August 2017

exact match

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cites work

Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid

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12 December 2020

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

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12 December 2020

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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12 December 2020

Effects of environmental enrichment on gene expression in the brain

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12 December 2020

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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12 December 2020

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

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12 December 2020

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

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12 December 2020

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

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12 December 2020

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

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12 December 2020

Evidence for the GluR6 gene associated with younger onset age of Huntington's disease

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12 December 2020

Huntington's disease gene product, huntingtin, associates with microtubules in vitro

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12 December 2020

Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation.

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12 December 2020

N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice

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12 December 2020

Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum

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12 December 2020

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

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12 December 2020

Pyramidal cell loss in motor cortices in Huntington's disease

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12 December 2020

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

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12 December 2020

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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12 December 2020

Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease

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12 December 2020

Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

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12 December 2020

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

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12 December 2020

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

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12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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12 December 2020

Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism

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12 December 2020

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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12 December 2020

Neural consequences of environmental enrichment

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12 December 2020

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

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12 December 2020

Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1

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12 December 2020

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

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12 December 2020

Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats

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12 December 2020

Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

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12 December 2020

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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12 December 2020

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

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12 December 2020

Brain-derived neurotrophic factor in Huntington disease

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12 December 2020

Anterior cingulate cortical transplantation in transgenic Huntington's disease mice

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12 December 2020

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

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12 December 2020

Transcriptional dysregulation in Huntington's disease

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12 December 2020

Crystalline fraction I protein: preparation in large yield

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12 December 2020

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

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12 December 2020

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.

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12 December 2020

Neurodegeneration: a failure of neuroregeneration?

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12 December 2020

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

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12 December 2020

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

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12 December 2020

Dynamic mutations: a new class of mutations causing human disease

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12 December 2020

Mechanism of altered synaptic strength due to experience: relation to long-term potentiation

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12 December 2020

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

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12 December 2020

Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

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12 December 2020

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

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12 December 2020

Transcriptional abnormalities in Huntington disease

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12 December 2020

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

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12 December 2020

Neurofilament and neural cell adhesion molecule immunocytochemistry of Huntington's disease striatum

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12 December 2020

Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice.

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12 December 2020

Enhancement of hippocampal field potentials in rats exposed to a novel, complex environment.

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12 December 2020

Trinucleotide repeat length instability and age of onset in Huntington's disease

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12 December 2020

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year.

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12 December 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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12 December 2020

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

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12 December 2020

Delaying the onset of Huntington's in mice

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12 December 2020

Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington's disease

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12 December 2020

More hippocampal neurons in adult mice living in an enriched environment

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12 December 2020

Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases

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12 December 2020

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

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12 December 2020

A mouse model of spinal and bulbar muscular atrophy.

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12 December 2020

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

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12 December 2020

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

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12 December 2020

Apoptosis in Huntington's disease.

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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12 December 2020

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

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12 December 2020

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

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12 December 2020

Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

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12 December 2020

10.1007/S10048-003-0169-5

Identifiers

DOI

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release_p4wrbrwozbfivhlk3sfaqvd56y

9 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/p4wrbrwozbfivhlk3sfaqvd56y

24 November 2022

mapped directly with Wikidata item

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