(Q35651729)

English

Hepatitis C. Development of new drugs and clinical trials: promises and pitfalls. Summary of an AASLD hepatitis single topic conference, Chicago, IL, February 27-March 1, 2003.

scientific article published on February 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

1 reference

Europe PubMed Central

Hepatitis C. Development of new drugs and clinical trials: promises and pitfalls. Summary of an AASLD hepatitis single topic conference, Chicago, IL, February 27-March 1, 2003. (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jean-Michel Pawlotsky

1

object named as

Jean-Michel Pawlotsky

0 references

author name string

Jean-Michel Pawlotsky

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

John G McHutchison

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

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publication date

1 February 2004

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

554-567

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection

1 reference

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In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus

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Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

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Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

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Effect of alpha interferon on the hepatitis C virus replicon

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Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

1 reference

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Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

1 reference

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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

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7 January 2021

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Cell-free replication of the hepatitis C virus subgenomic replicon

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Hepatitis C Virus RNA Synthesis in a Cell-Free System Isolated from Replicon-Containing Hepatoma Cells

1 reference

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In vitro RNA replication directed by replicase complexes isolated from the subgenomic replicon cells of hepatitis C virus

1 reference

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Advances in model systems for hepatitis C virus research

1 reference

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7 January 2021

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Transmission of hepatitis C virus infection to tree shrews

1 reference

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The hepatitis C virus (HCV)-Trimera mouse: a model for evaluation of agents against HCV.

1 reference

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7 January 2021

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Hepatitis C virus replication in mice with chimeric human livers

1 reference

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7 January 2021

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Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans

1 reference

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7 January 2021

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Clinical importance of the cytochromes P450

1 reference

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PXR, CAR and drug metabolism

1 reference

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7 January 2021

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Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition

1 reference

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7 January 2021

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Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

1 reference

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7 January 2021

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Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus

1 reference

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7 January 2021

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Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha2a

1 reference

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7 January 2021

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First phase viral kinetic parameters as predictors of treatment response and their influence on the second phase viral decline

1 reference

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7 January 2021

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Hepatitis C viral kinetics in difficult to treat patients receiving high dose interferon and ribavirin

1 reference

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7 January 2021

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Ultrarapid hepatitis C virus clearance by daily high-dose interferon in non-responders to standard therapy

1 reference

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7 January 2021

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Estimation of early hepatitis C viral clearance in patients receiving daily interferon and ribavirin therapy using a mathematical model

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

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Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C.

1 reference

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7 January 2021

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Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA Panel.

1 reference

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7 January 2021

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The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs

1 reference

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7 January 2021

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Structure-function analysis of the 3' stem-loop of hepatitis C virus genomic RNA and its role in viral RNA replication

1 reference

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7 January 2021

based on heuristic

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Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit

1 reference

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7 January 2021

based on heuristic

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

1 reference

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7 January 2021

based on heuristic

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The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

1 reference

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7 January 2021

based on heuristic

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Inhibiting viral proteases: challenges and opportunities

1 reference

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7 January 2021

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Peptidic inhibitors of the hepatitis C virus serine protease within non-structural protein 3.

1 reference

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7 January 2021

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Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy

1 reference

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7 January 2021

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

1 reference

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7 January 2021

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Helicase structure and mechanism

1 reference

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7 January 2021

based on heuristic

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1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

1 reference

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7 January 2021

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

1 reference

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7 January 2021

based on heuristic

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

1 reference

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7 January 2021

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of hepatitis C virus to CD81

1 reference

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7 January 2021

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The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetics of CD4+ and CD8+ Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Peginterferon alone or with ribavirin enhances HCV-specific CD4 T-helper 1 responses in patients with chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Liver fibrosis -- from bench to bedside

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The human interferon alpha species and receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The IFN gamma receptor: a paradigm for cytokine receptor signaling

1 reference

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7 January 2021

based on heuristic

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IL-28, IL-29 and their class II cytokine receptor IL-28R

1 reference

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7 January 2021

based on heuristic

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The biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferon

1 reference

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7 January 2021

based on heuristic

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Treatment of chronic hepatitis C with consensus interferon: a multicenter, randomized, controlled trial. Consensus Interferon Study Group

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evolution of a cytokine using DNA family shuffling

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Imiquimod and resiquimod as novel immunomodulators

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Administration of imiquimod, an interferon inducer, in asymptomatic human immunodeficiency virus-infected persons to determine safety and biologic response modification

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Imiquimod-elicited emesis is mediated by the area postrema, but not by direct neuronal activation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of action of ribavirin in the combination treatment of chronic HCV infection

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Maxamine. Histamine dihydrochloride

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis B viral genotypes and lamivudine resistance.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA interference

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

New therapies on the horizon for hepatitis C: are we close?

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Persistence of YMDD variants after withdrawal of Lamivudine.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

HCV RNA-dependent RNA polymerase as a target for antiviral development

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Long term response to interferon treatment in chronic hepatitis C patients is associated with a significant reduction in anti-E1 envelope antibody titers

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibodies against hepatitis C virus-like particles and viral clearance in acute and chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.20065

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/HEP.20065

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

0 references

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