(Q35666558)

English

Discovery of safe and orally effective 4-aminoquinaldine analogues as apoptotic inducers with activity against experimental visceral leishmaniasis.

scientific article published on 24 October 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Discovery of safe and orally effective 4-aminoquinaldine analogues as apoptotic inducers with activity against experimental visceral leishmaniasis (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

apoptotic process

0 references

visceral leishmaniasis

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

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15 January 2020

3

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15 January 2020

Prabu Manoharan

5

1 reference

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15 January 2020

7

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15 January 2020

author name string

Partha Palit

1

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15 January 2020

R S K Vijayan

4

1 reference

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15 January 2020

Sukdeb Banerjee

6

1 reference

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15 January 2020

Nanda Ghoshal

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Nahid Ali

9

1 reference

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15 January 2020

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publication date

24 October 2011

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15 January 2020

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

56

1 reference

Europe PubMed Central

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15 January 2020

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

432-445

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

In vitro activities of new 2-substituted quinolines against Leishmania donovani

1 reference

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Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.

1 reference

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27 July 2018

Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine

1 reference

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27 July 2018

Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence.

1 reference

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27 July 2018

Hybrid structure-based virtual screening protocol for the identification of novel BACE1 inhibitors

1 reference

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27 July 2018

Fighting against Leishmaniasis: search of alkaloids as future true potential anti-Leishmanial agents

1 reference

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27 July 2018

Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Chemotherapy of leishmaniasis: past, present and future

1 reference

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27 July 2018

Drug discovery and development for neglected parasitic diseases

1 reference

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27 July 2018

Response from Savioli and colleagues from the Department of Neglected Tropical Diseases, World Health Organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Current scenario of drug development for leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Efficacy of orally administered 2-substituted quinolines in experimental murine cutaneous and visceral leishmaniases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Recent advances in antileishmanial drug development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Synthesis and antileishmanial activities of novel 3-substituted quinolines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

New drugs for neglected diseases: from pipeline to patients

1 reference

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27 July 2018

Combination therapy using sodium antimony gluconate in stearylamine-bearing liposomes against established and chronic Leishmania donovani infection in BALB/c Mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

On the origin, evolution, and nature of programmed cell death: a timeline of four billion years

1 reference

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27 July 2018

Phosphatidylserine, a death knell

1 reference

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27 July 2018

Heterogeneity of clara cell glutathione. A possible basis for differences in cellular responses to pulmonary cytotoxicants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Antileishmanial activities of stearylamine-bearing liposomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256064

27 July 2018

Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis

1 reference

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27 July 2018

Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling

1 reference

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27 July 2018

Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes.

1 reference

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27 July 2018

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

1 reference

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27 July 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

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27 July 2018

Increase of dihydrofolate reductase in peripheral blood lymphocytes of rheumatoid arthritis patients treated with low-dose oral methotrexate.

1 reference

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27 July 2018

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

1 reference

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27 July 2018

2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase

1 reference

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27 July 2018

Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors

1 reference

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27 July 2018

DNA fragmentation, dATP pool elevation and potentiation of antifolate cytotoxicity in L1210 cells by hypoxanthine

1 reference

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Metabolism and functions of trypanothione in the Kinetoplastida

1 reference

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Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase

1 reference

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27 July 2018

Probing the structure of Leishmania donovani chagasi DHFR-TS: comparative protein modeling and protein-ligand interaction studies

1 reference

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Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.

1 reference

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25 September 2018

Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

1 reference

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25 September 2018

Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani

1 reference

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Innovative lead discovery strategies for tropical diseases

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25 September 2018

The antifolate activity of tea catechins.

1 reference

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25 September 2018

Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani

1 reference

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25 September 2018

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines

1 reference

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25 September 2018

Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide--a potential antileishmanial agent

1 reference

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25 September 2018

Programmed cell death in the unicellular protozoan parasite Leishmania

1 reference

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25 September 2018

Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes

1 reference

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25 September 2018

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

1 reference

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25 September 2018

Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes.

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25 September 2018

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

1 reference

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25 September 2018

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed

1 reference

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12 December 2020

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Therapeutic trial in experimental tegumentary leishmaniasis caused by Leishmania (Leishmania) amazonensis. A comparative study between mefloquine and aminosidine

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The treatment of kala-azar--new approaches to an old problem

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Intracellular development of choleraphage phi 149 under permissive and nonpermissive conditions: an electron microscopic study

1 reference

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12 December 2020

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1 reference

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Characterization of mitochondrial electron-transfer in Leishmania mexicana

1 reference

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12 December 2020

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Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00700-11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22024817%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

ResearchGate publication ID

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