(Q35666691)

9 August 2017

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title

B-cell homeostasis: digital survival or analog growth? (English)

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9 August 2017

Jeffrey C Rathmell

1

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9 August 2017

publication date

1 February 2004

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9 August 2017

published in

Immunological Reviews

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9 August 2017

volume

197

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9 August 2017

page(s)

116-128

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Homeostasis of alpha beta TCR+ T cells.

9 August 2017

cites work

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Size control in animal development

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Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo

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Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

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The mechanism and regulation of chromosomal V(D)J recombination

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Role of B cell antigen receptor in regulation of V(D)J recombination and cell survival

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Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

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Interleukin-7: from bench to clinic

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Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements

21 January 2018

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EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells

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Inhibition of interleukin 7 receptor signaling by antigen receptor assembly

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B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

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Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation

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CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals.

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Transitional B cells: step by step towards immune competence

21 January 2018

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BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

21 January 2018

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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

21 January 2018

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Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase

21 January 2018

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

21 January 2018

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Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

21 January 2018

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BAFF mediates survival of peripheral immature B lymphocytes

21 January 2018

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Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response

21 January 2018

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Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators.

21 January 2018

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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

21 January 2018

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Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

21 January 2018

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Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice.

21 January 2018

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NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily

21 January 2018

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The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

An intact NF-kappa B signaling pathway is required for maintenance of mature B cell subsets

21 January 2018

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IkappaB kinase alpha is essential for mature B cell development and function

21 January 2018

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IkappaB kinase signaling is essential for maintenance of mature B cells

21 January 2018

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The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2.

21 January 2018

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CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction

21 January 2018

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Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development

21 January 2018

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Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis

21 January 2018

1 reference

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BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

21 January 2018

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

21 January 2018

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BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2

21 January 2018

1 reference

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TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase

21 January 2018

1 reference

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Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

BAFF AND APRIL: a tutorial on B cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Apoptosis in the development and maintenance of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Growth factors can influence cell growth and survival through effects on glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

IL-7 enhances the survival and maintains the size of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

The importance of glutathione in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: relationship to caspase activity and the loss of glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Reactive oxygen species differentially affect T cell receptor-signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Role of oxidative phosphorylation in Bax toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bax-induced cell death in yeast depends on mitochondrial lipid oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Growth signaling: TSC takes its place.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

c-Myc enhances protein synthesis and cell size during B lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

c-Myc regulates mammalian body size by controlling cell number but not cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.0096.X

10.1111/J.0105-2896.2004.0096.X

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference