(Q35668881)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Klemens Kaupmann

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Barbara Baldo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Andreas Weiss

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Christian N Parker

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Miriam Bibel

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

28 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

number of pages

9

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

1406-1414

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

17 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3256905/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Hsp70 and its molecular role in nervous system diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Oligonucleotide therapeutic approaches for Huntington disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Huntington's disease: from molecular pathogenesis to clinical treatment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Co-chaperones are limiting in a depleted chaperone network

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Heat shock protein 90 in neurodegenerative diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Development of a method for the high-throughput quantification of cellular proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Small molecule drug discovery for Huntington's Disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

The ground state of embryonic stem cell self-renewal

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Neurological abnormalities in a knock-in mouse model of Huntington's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Hsp90 as a capacitor for morphological evolution

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Inactivation of the mouse Huntington's disease gene homolog Hdh

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

12 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Neuronal cells show regulatory differences in the hsp70 gene response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Hsp90 inhibitors as selective anticancer drugs.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256905

Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells

25 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.294801

Binding of p23 and hsp90 during assembly with the progesterone receptor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22123826

12 December 2020

inferred from PubMed ID database lookup

Development and implementation of a highly miniaturized confocal 2D-FIDA-based high-throughput screening assay to search for active site modulators of the human heat shock protein 90beta

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22123826

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M111.294801

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22123826%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

22123826

1 reference